Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study

TA Jusko, PA Shaw, Claudia Snijder, FH Pierik, HM Koch, R Hauser, Vincent Jaddoe, Lex Burdorf, Bert Hofman, Henning Tiemeier, MR Longnecker

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Abstract

The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at <18, 18-25, and >25 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18-0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16-0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.
Original languageUndefined/Unknown
Pages (from-to)532-536
Number of pages5
JournalJournal of Exposure Science and Environmental Epidemiology
Volume24
Issue number5
DOIs
Publication statusPublished - 2014

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