Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer: A DCCSS-LATER study

Joyce J.M. Claessens*, Adriaan Penson, Ewald M. Bronkhorst, Leontien C.M. Kremer, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Wim J.E. Tissing, Helena J.H. van der Pal, Nicole M.A. Blijlevens, Marry M. van den Heuvel-Eibrink, A. Birgitta Versluys, Dorine Bresters, Cécile M. Ronckers, Iris Walraven, Catharina C.M. Beerendonk, Jacqueline J. Loonen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Treatment-related gonadal dysfunction leading to fertility problems is a frequently encountered late effect in childhood cancer survivors (CCSs). This study evaluated reproductive outcomes and reproductive health care utilization among male CCSs compared with male siblings. 


A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor LATER study part 1, a questionnaire and linkage study. A questionnaire addressing reproductive outcomes and reproductive health care was completed by 1317 male CCSs and 407 male siblings. A total of 491 CCSs and 185 siblings had a previous or current desire for children and were included in this study. 


Fewer CCSs had biological children compared with siblings (65% vs. 88%; p <.001). The type of conception by men who fathered a child was comparable between CCSs and siblings (spontaneous conception of 90% of both groups; p =.86). The percentage of men who had consulted a reproductive specialist because of not siring a pregnancy was higher in CCSs compared with siblings (34% vs. 12%; p <.001). Following consultation, fewer CCSs underwent assisted reproductive techniques (ART) compared with siblings (41% vs. 77%; p =.001). After ART, fewer CCSs fathered a child compared with siblings (49% vs. 94%; p =.001). 


More male survivors consult a reproductive specialist, but fewer survivors undergo ART and father a child after ART compared with siblings. This insight is important for understanding potential problems faced by survivors regarding family planning and emphasizes the importance of collaboration between oncologists and reproductive specialists.

Original languageEnglish
Pages (from-to)995-1004
Number of pages10
Issue number6
Early online date6 Dec 2023
Publication statusPublished - 15 Mar 2024

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Publisher Copyright:
© 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.


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