Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells

Laurens W.J. Bosman, Jana Hartmann, Jaroslaw J. Barski, Alexandra Lepier, Michael Noll-Hussong, Louis F. Reichardt, Arthur Konnerth*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast to other types of neurons, Purkinje cells do not need TrkB for dendritic growth and spine formation. Instead, we find a moderate delay in the maturation of GABAergic synapses and, more importantly, an abnormal multiple climbing fiber innervation in Purkinje cells in trkB-deficient mice. Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain.

Original languageEnglish
Pages (from-to)87-101
Number of pages15
JournalBrain Cell Biology
Volume35
Issue number1
DOIs
Publication statusPublished - Feb 2006

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