Residual breast tissue after mastectomy and reconstruction: A substudy of the Spatial location of breast cancer local rECurRence aftEr masTectomy (SECRET) project

Orit Kaidar-Person*, Miri Sklair-Levy, Debbie Anaby, The SECRET group, Rinat Bernstein-Molho, Marissa C. van Maaren, Linda de Munck, Dirk de Ruysscher, Birgitte Offersen, Philip Poortmans, Liesbeth Jorinne Boersma, M. B.E. Menke-Pluijmers, A. Doeksen, F. van Vliet-Moret, C. Bargon, L. Strobbe, M. Bindels, J. Volders, J. Simons, A. Verbeek de KanterM. Mast, G. de Vos, M. Bessems, L. van Zutphen, M. van Erp, C. Finaly-Marais, K. Schenk, M. Smidt, A. Huiberts, J. Muijsenberg, R. Swart, A. Cobussen, L. Boersma, S. Oostwegel, J. Veugen, P. Westhoff, S. Wooldrik, T. Klem, A. Scholten, F. van Duijnhoven, J. P. van Olmen, F. van der Leij, K. Verschueren, F. Aarts, T. Schok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The current project is part of the Spatial location of breast cancer local rECurRence aftEr masTectomy (SECRET) study (NCT06130111). Herein we compared the chest wall thickness after non-skin sparing mastectomy (non-SSM) with the chest wall thickness after SSM, as a surrogate for residual breast tissue after mastectomy. Methods: The study was approved by the ethics committee of relevant institutions. Data of patients with a local recurrence (LR) after non-SSM was collected from the Netherlands Cancer Registry (NCR); data of patients undergoing SSM were collected from Sheba Medical Center. Student's t-test was used to evaluate the difference between the cohorts. Chest wall thickness was measured on postoperative images. Results: Out of 4949 patients who underwent mastectomy from the NCR cohort, a total of 173 (3.5 %) had a LR at 5 years, of these a total of 153 patients included in the non-SSM cohort. The median age was 59 years (age 33–92), LR occurred at a median of 23.6 months (2.5–60 months). The SSM cohort included 84 patients, with a median age of 38.4 years (28–63.5), overall, 5 LRs occurred at a median of 15 months (5–46 months). The SSM cohort had significantly thicker chest walls compared to non-SSM (p < 0.001). Most LRs in both groups occurred in the subcutis. Conclusion: The chest wall thickness differed according to mastectomy procedures. Most of the LR occurred at the subcutis. The role of residual breast tissue and residual cancer in relation to type of mastectomy should be further investigated.

Original languageEnglish
Article number108607
JournalEuropean Journal of Surgical Oncology
Volume50
Issue number11
DOIs
Publication statusPublished - Nov 2024

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Publisher Copyright:
© 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology

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