Response: Re: Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells

Anieta Sieuwerts; Jaco Kraan; Joan Vries; Petra Spoel; F Elstrodt; Marcel Smid; Mieke Timmermans; Bianca Mostert; Mieke Schutte; John Martens; Jan willem Gratama; Stefan Sleijfer; John Foekens

doi:10.1093/jnci/djp118

Response: Re: Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells

Anieta Sieuwerts, Jaco Kraan, Joan Vries, Petra Spoel, F Elstrodt, Marcel Smid, Mieke Timmermans, Bianca Mostert, Mieke Schutte, John Martens, Jan willem Gratama, Stefan Sleijfer, John Foekens

Research output: Contribution to journal › Article › Academic › peer-review

372 Citations (Scopus)

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Abstract

The enumeration of circulating tumor cells (CTCs) holds great promise for clinical decision making. The CellSearch method has proven prognostic value in advanced breast, colorectal, and prostate cancers. However, this fact does not imply that there is no room for improvement. As mentioned by Hayes and Cristofanilli, CTCs cannot be detected in a substantial number of patients with metastatic breast cancer. Lack of expression of a marker essential for CTC detection may account for this problem. Epithelial cell adhesion molecule (EpCAM) expression on CTCs is crucial for several CTC assays. However, as acknowledged by Hayes and Cristofanilli and by Connelly and colleagues, EpCAM is not a perfect marker. [...]

Original language	Undefined/Unknown
Pages (from-to)	896-897
Number of pages	2
Journal	Journal of the National Cancer Institute
Volume	101
Issue number	12
DOIs	https://doi.org/10.1093/jnci/djp118
Publication status	Published - 16 Jun 2009

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10.1093/jnci/djp118

372 Citations
1 Article

Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells
Sieuwerts, A., Kraan, J., Vries, J., Spoel, P., Elstrodt, F., Schutte, M., Martens, J., Gratama, J. W., Sleijfer, S. & Foekens, J., 2009, In: Journal of the National Cancer Institute. 101, 1, p. 61-66 6 p.
Research output: Contribution to journal › Article › Academic › peer-review

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12 Citations (Scopus)

26 Downloads (Pure)

Cite this

Sieuwerts, A., Kraan, J., Vries, J., Spoel, P., Elstrodt, F., Smid, M., Timmermans, M., Mostert, B., Schutte, M., Martens, J., Gratama, J. W., Sleijfer, S., & Foekens, J. (2009). Response: Re: Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells. Journal of the National Cancer Institute, 101(12), 896-897. https://doi.org/10.1093/jnci/djp118

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abstract = "The enumeration of circulating tumor cells (CTCs) holds great promise for clinical decision making. The CellSearch method has proven prognostic value in advanced breast, colorectal, and prostate cancers. However, this fact does not imply that there is no room for improvement. As mentioned by Hayes and Cristofanilli, CTCs cannot be detected in a substantial number of patients with metastatic breast cancer. Lack of expression of a marker essential for CTC detection may account for this problem. Epithelial cell adhesion molecule (EpCAM) expression on CTCs is crucial for several CTC assays. However, as acknowledged by Hayes and Cristofanilli and by Connelly and colleagues, EpCAM is not a perfect marker. [...]",

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Sieuwerts, A, Kraan, J, Vries, J, Spoel, P, Elstrodt, F, Smid, M, Timmermans, M, Mostert, B, Schutte, M, Martens, J , Gratama, JW , Sleijfer, S & Foekens, J 2009, 'Response: Re: Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells', Journal of the National Cancer Institute, vol. 101, no. 12, pp. 896-897. https://doi.org/10.1093/jnci/djp118

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AU - Sieuwerts, Anieta

AU - Kraan, Jaco

AU - Vries, Joan

AU - Spoel, Petra

AU - Elstrodt, F

AU - Smid, Marcel

AU - Timmermans, Mieke

AU - Mostert, Bianca

AU - Schutte, Mieke

AU - Martens, John

AU - Gratama, Jan willem

AU - Sleijfer, Stefan

AU - Foekens, John

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AB - The enumeration of circulating tumor cells (CTCs) holds great promise for clinical decision making. The CellSearch method has proven prognostic value in advanced breast, colorectal, and prostate cancers. However, this fact does not imply that there is no room for improvement. As mentioned by Hayes and Cristofanilli, CTCs cannot be detected in a substantial number of patients with metastatic breast cancer. Lack of expression of a marker essential for CTC detection may account for this problem. Epithelial cell adhesion molecule (EpCAM) expression on CTCs is crucial for several CTC assays. However, as acknowledged by Hayes and Cristofanilli and by Connelly and colleagues, EpCAM is not a perfect marker. [...]

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