Response: Re: Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells

Anieta Sieuwerts, Jaco Kraan, Joan Vries, Petra Spoel, F Elstrodt, Marcel Smid, Mieke Timmermans, Bianca Mostert, Mieke Schutte, John Martens, Jan willem Gratama, Stefan Sleijfer, John Foekens

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The enumeration of circulating tumor cells (CTCs) holds great promise for clinical decision making. The CellSearch method has proven prognostic value in advanced breast, colorectal, and prostate cancers. However, this fact does not imply that there is no room for improvement. As mentioned by Hayes and Cristofanilli, CTCs cannot be detected in a substantial number of patients with metastatic breast cancer. Lack of expression of a marker essential for CTC detection may account for this problem. Epithelial cell adhesion molecule (EpCAM) expression on CTCs is crucial for several CTC assays. However, as acknowledged by Hayes and Cristofanilli and by Connelly and colleagues, EpCAM is not a perfect marker. [...]
Original languageUndefined/Unknown
Pages (from-to)896-897
Number of pages2
JournalJournal of the National Cancer Institute
Issue number12
Publication statusPublished - 16 Jun 2009

Research programs

  • EMC MM-03-86-12

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