Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases

M J van Amerongen; E P van der Stok; J J Fütterer; S F M Jenniskens; A Moelker; C Verhoef; D J Grünhagen; J H W de Wilt

doi:10.1016/j.ejso.2019.07.016

Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases

M J van Amerongen^*, E P van der Stok, J J Fütterer, S F M Jenniskens, A Moelker, C Verhoef, D J Grünhagen, J H W de Wilt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND: Approximately 20% of patients with colorectal cancer present with synchronous liver metastases (sCRLM). These patients can be treated with a "one-step procedure" or staged resection, with or without radiofrequency ablation (RFA). Colorectal surgery in combination with intraoperative RFA leads to concerns regarding postoperative complications and survival. The purpose was to evaluate the one-step procedure with or without RFA in patients with sCRLM.

MATERIALS AND METHODS: Between January 2000 and September 2018, patients with sCRLM were selected in two tertiary referral centers and retrospectively analyzed. Postoperative morbidity and survival were analyzed.

RESULTS: From a total of 410 patients presenting with sCRLM, 329 patients underwent a staged resection and 81 a one-step procedure. The 3-year overall survival (OS) was respectively 66% and 69% for one-step procedure and staged resection (P = 0.24). A total of 18 patients underwent RFA during the one step procedure. No significant differences were shown in postoperative complications whether intraoperative RFA was used in patients with sCRLM. In the one-step procedure, the 3-year OS was respectively 43% and 72% wheter patients did or did not receive RFA (P = 0.19).

CONCLUSION: OS for patients with sCRLM was similar for both one-step procedure and staged resection. Intraoperative RFA for sCRLM is technically safe.

Original language	English
Pages (from-to)	2334-2339
Number of pages	6
Journal	European Journal of Surgical Oncology
Volume	45
Issue number	12
Early online date	7 Jul 2019
DOIs	https://doi.org/10.1016/j.ejso.2019.07.016
Publication status	Published - 1 Dec 2019

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van Amerongen, M. J., van der Stok, E. P., Fütterer, J. J., Jenniskens, S. F. M., Moelker, A., Verhoef, C., Grünhagen, D. J., & de Wilt, J. H. W. (2019). Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases. European Journal of Surgical Oncology, 45(12), 2334-2339. Advance online publication. https://doi.org/10.1016/j.ejso.2019.07.016

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title = "Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases",

abstract = "BACKGROUND: Approximately 20% of patients with colorectal cancer present with synchronous liver metastases (sCRLM). These patients can be treated with a {"}one-step procedure{"} or staged resection, with or without radiofrequency ablation (RFA). Colorectal surgery in combination with intraoperative RFA leads to concerns regarding postoperative complications and survival. The purpose was to evaluate the one-step procedure with or without RFA in patients with sCRLM.MATERIALS AND METHODS: Between January 2000 and September 2018, patients with sCRLM were selected in two tertiary referral centers and retrospectively analyzed. Postoperative morbidity and survival were analyzed.RESULTS: From a total of 410 patients presenting with sCRLM, 329 patients underwent a staged resection and 81 a one-step procedure. The 3-year overall survival (OS) was respectively 66% and 69% for one-step procedure and staged resection (P = 0.24). A total of 18 patients underwent RFA during the one step procedure. No significant differences were shown in postoperative complications whether intraoperative RFA was used in patients with sCRLM. In the one-step procedure, the 3-year OS was respectively 43% and 72% wheter patients did or did not receive RFA (P = 0.19).CONCLUSION: OS for patients with sCRLM was similar for both one-step procedure and staged resection. Intraoperative RFA for sCRLM is technically safe.",

author = "{van Amerongen}, {M J} and {van der Stok}, {E P} and F{\"u}tterer, {J J} and Jenniskens, {S F M} and A Moelker and C Verhoef and Gr{\"u}nhagen, {D J} and {de Wilt}, {J H W}",

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doi = "10.1016/j.ejso.2019.07.016",

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van Amerongen, MJ, van der Stok, EP, Fütterer, JJ, Jenniskens, SFM, Moelker, A, Verhoef, C , Grünhagen, DJ & de Wilt, JHW 2019, 'Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases', European Journal of Surgical Oncology, vol. 45, no. 12, pp. 2334-2339. https://doi.org/10.1016/j.ejso.2019.07.016

TY - JOUR

T1 - Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases

AU - van Amerongen, M J

AU - van der Stok, E P

AU - Fütterer, J J

AU - Jenniskens, S F M

AU - Moelker, A

AU - Verhoef, C

AU - Grünhagen, D J

AU - de Wilt, J H W

PY - 2019/12/1

Y1 - 2019/12/1

N2 - BACKGROUND: Approximately 20% of patients with colorectal cancer present with synchronous liver metastases (sCRLM). These patients can be treated with a "one-step procedure" or staged resection, with or without radiofrequency ablation (RFA). Colorectal surgery in combination with intraoperative RFA leads to concerns regarding postoperative complications and survival. The purpose was to evaluate the one-step procedure with or without RFA in patients with sCRLM.MATERIALS AND METHODS: Between January 2000 and September 2018, patients with sCRLM were selected in two tertiary referral centers and retrospectively analyzed. Postoperative morbidity and survival were analyzed.RESULTS: From a total of 410 patients presenting with sCRLM, 329 patients underwent a staged resection and 81 a one-step procedure. The 3-year overall survival (OS) was respectively 66% and 69% for one-step procedure and staged resection (P = 0.24). A total of 18 patients underwent RFA during the one step procedure. No significant differences were shown in postoperative complications whether intraoperative RFA was used in patients with sCRLM. In the one-step procedure, the 3-year OS was respectively 43% and 72% wheter patients did or did not receive RFA (P = 0.19).CONCLUSION: OS for patients with sCRLM was similar for both one-step procedure and staged resection. Intraoperative RFA for sCRLM is technically safe.

AB - BACKGROUND: Approximately 20% of patients with colorectal cancer present with synchronous liver metastases (sCRLM). These patients can be treated with a "one-step procedure" or staged resection, with or without radiofrequency ablation (RFA). Colorectal surgery in combination with intraoperative RFA leads to concerns regarding postoperative complications and survival. The purpose was to evaluate the one-step procedure with or without RFA in patients with sCRLM.MATERIALS AND METHODS: Between January 2000 and September 2018, patients with sCRLM were selected in two tertiary referral centers and retrospectively analyzed. Postoperative morbidity and survival were analyzed.RESULTS: From a total of 410 patients presenting with sCRLM, 329 patients underwent a staged resection and 81 a one-step procedure. The 3-year overall survival (OS) was respectively 66% and 69% for one-step procedure and staged resection (P = 0.24). A total of 18 patients underwent RFA during the one step procedure. No significant differences were shown in postoperative complications whether intraoperative RFA was used in patients with sCRLM. In the one-step procedure, the 3-year OS was respectively 43% and 72% wheter patients did or did not receive RFA (P = 0.19).CONCLUSION: OS for patients with sCRLM was similar for both one-step procedure and staged resection. Intraoperative RFA for sCRLM is technically safe.

U2 - 10.1016/j.ejso.2019.07.016

DO - 10.1016/j.ejso.2019.07.016

M3 - Article

C2 - 31301939

SN - 0748-7983

VL - 45

SP - 2334

EP - 2339

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 12

ER -

Results after simultaneous surgery and RFA liver ablation for patients with colorectal carcinoma and synchronous liver metastases

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