Retinal neurodegeneration and brain MRI markers: the Rotterdam Study

Unal Mutlu; Pieter W.M. Bonnemaijer; M. Arfan Ikram; Johanna M. Colijn; Lotte G.M. Cremers; Gabriëlle H.S. Buitendijk; Johannes R. Vingerling; Wiro J. Niessen; Meike W. Vernooij; Caroline C.W. Klaver; M. Kamran Ikram

doi:10.1016/j.neurobiolaging.2017.09.003

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study

Unal Mutlu, Pieter W.M. Bonnemaijer, M. Arfan Ikram, Johanna M. Colijn, Lotte G.M. Cremers, Gabriëlle H.S. Buitendijk, Johannes R. Vingerling, Wiro J. Niessen, Meike W. Vernooij, Caroline C.W. Klaver, M. Kamran Ikram^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

77 Citations (Scopus)

Abstract

We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.

Original language	English
Pages (from-to)	183-191
Number of pages	9
Journal	Neurobiology of Aging
Volume	60
DOIs	https://doi.org/10.1016/j.neurobiolaging.2017.09.003
Publication status	Published - Dec 2017

Bibliographical note

Funding Information:
The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam , Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science , the Ministry for Health, Welfare and Sports , the European Commission (DG XII) , and the Municipality of Rotterdam .

Publisher Copyright:
© 2017 Elsevier Inc.

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EMC NIHES-03-30-02

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10.1016/j.neurobiolaging.2017.09.003

http://hdl.handle.net/1765/108489

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@article{41f66b69b46749fb896e6dd6f98cbd64,

title = "Retinal neurodegeneration and brain MRI markers: the Rotterdam Study",

abstract = "We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.",

author = "Unal Mutlu and Bonnemaijer, {Pieter W.M.} and Ikram, {M. Arfan} and Colijn, {Johanna M.} and Cremers, {Lotte G.M.} and Buitendijk, {Gabri{\"e}lle H.S.} and Vingerling, {Johannes R.} and Niessen, {Wiro J.} and Vernooij, {Meike W.} and Klaver, {Caroline C.W.} and Ikram, {M. Kamran}",

note = "Funding Information: The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam , Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science , the Ministry for Health, Welfare and Sports , the European Commission (DG XII) , and the Municipality of Rotterdam . Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = dec,

doi = "10.1016/j.neurobiolaging.2017.09.003",

language = "English",

volume = "60",

pages = "183--191",

journal = "Neurobiology of Aging",

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AU - Mutlu, Unal

AU - Bonnemaijer, Pieter W.M.

AU - Ikram, M. Arfan

AU - Colijn, Johanna M.

AU - Cremers, Lotte G.M.

AU - Buitendijk, Gabriëlle H.S.

AU - Vingerling, Johannes R.

AU - Niessen, Wiro J.

AU - Vernooij, Meike W.

AU - Klaver, Caroline C.W.

AU - Ikram, M. Kamran

N1 - Funding Information: The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam , Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science , the Ministry for Health, Welfare and Sports , the European Commission (DG XII) , and the Municipality of Rotterdam . Publisher Copyright: © 2017 Elsevier Inc.

PY - 2017/12

Y1 - 2017/12

N2 - We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.

AB - We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT images and brain MRI scans. Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images. Volumetric, microstructural, and focal markers of brain tissue were assessed on MRI. We found that thinner RNFL, GCL, and inner plexiform layer were associated with smaller gray-matter and white-matter volume. Furthermore, we found that thinner RNFL and GCL were associated with worse white-matter microstructure. No association was found between retinal sublayer thickness and white-matter lesion volumes, cerebral microbleeds, or lacunar infarcts. Markers of retinal neurodegeneration are associated with markers of cerebral atrophy, suggesting that retinal OCT may provide information on neurodegeneration in the brain.

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SP - 183

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study

Abstract

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