Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes-proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS

A Porwit, AA van de Loosdrecht, P Bettelheim, LE Brodersen, K Burbury, E Cremers, MG Della Porta, R Ireland, U Johansson, S Matarraz, K Ogata, A Orfao, F Preijers, K Psarra, D Subiraa, P Valent, Vincent van der Velden, D Wells, TM Westers, W KernMC Bene

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103 Citations (Scopus)

Abstract

Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid neoplasms. An international working party initiated within the European LeukemiaNet and extended to include members from Australia, Canada, Japan, Taiwan and the United States has, through several workshops, developed and subsequently published consensus recommendations. The latter deal with preanalytical precautions, and propose small and large panels, which allow evaluating immunophenotypic anomalies and calculating myelodysplasia scores. The current paper provides guidelines that strongly recommend the integration of FCM data with other diagnostic tools in the diagnostic work-up of MDS.
Original languageUndefined/Unknown
Pages (from-to)1793-1798
Number of pages6
JournalLeukemia
Volume28
Issue number9
DOIs
Publication statusPublished - 2014

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