Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Thomas M. Gorter; Dirk J. van Veldhuisen; Johann Bauersachs; Barry A. Borlaug; Jelena Celutkiene; Andrew J.S. Coats; Marisa G. Crespo-Leiro; Marco Guazzi; Veli Pekka Harjola; Stephane Heymans; Loreena Hill; Mitja Lainscak; Carolyn S.P. Lam; Lars H. Lund; Alexander R. Lyon; Alexandre Mebazaa; Christian Mueller; Walter J. Paulus; Burkert Pieske; Massimo F. Piepoli; Frank Ruschitzka; Frans H. Rutten; Petar M. Seferovic; Scott D. Solomon; Sanjiv J. Shah; Filippos Triposkiadis; Rolf Wachter; Carsten Tschöpe; Rudolf A. de Boer

doi:10.1002/ejhf.1029

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Thomas M. Gorter
, Dirk J. van Veldhuisen
, Johann Bauersachs
, Barry A. Borlaug
, Jelena Celutkiene
, Andrew J.S. Coats
, Marisa G. Crespo-Leiro
, Marco Guazzi
, Veli Pekka Harjola
, Stephane Heymans
, Loreena Hill
, Mitja Lainscak
, Carolyn S.P. Lam
, Lars H. Lund
, Alexander R. Lyon
, Alexandre Mebazaa
, Christian Mueller
, Walter J. Paulus
, Burkert Pieske
, Massimo F. Piepoli

Frank Ruschitzka, Frans H. Rutten, Petar M. Seferovic, Scott D. Solomon, Sanjiv J. Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschöpe, Rudolf A. de Boer^*

^*Corresponding author for this work

University Medical Centre Groningen
Hannover Medical School
Mayo Clinic Rochester, MN
Vilnius University
Monash University
University of Warwick
University of A Coruna
University of Milan
University of Helsinki
Maastricht University
Queen's University Belfast
General Hospital Murska Sobota
National Heart Centre Singapore
Karolinska University Hospital
National Heart and Lung Institute
Assistance publique – Hôpitaux de Paris
Universitätsspital Basel
VU University Medical Center
Charité – Universitätsmedizin Berlin
Guglielmo da Saliceto Hospital
University Hospital Zürich
University Medical Centre Utrecht
Clinical Center of Serbia
Harvard Medical School
Northwestern University
University Hospital of Larissa
University Hospital Leipzig
University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

319 Citations (Scopus)

Abstract

There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

Original language	English
Pages (from-to)	16-37
Number of pages	22
Journal	European Journal of Heart Failure
Volume	20
Issue number	1
DOIs	https://doi.org/10.1002/ejhf.1029
Publication status	Published - Jan 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology

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Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V. P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029

@article{958e2781e8b546498e6b61cdb30532a5,

title = "Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology",

abstract = "There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.",

author = "Gorter, \{Thomas M.\} and \{van Veldhuisen\}, \{Dirk J.\} and Johann Bauersachs and Borlaug, \{Barry A.\} and Jelena Celutkiene and Coats, \{Andrew J.S.\} and Crespo-Leiro, \{Marisa G.\} and Marco Guazzi and Harjola, \{Veli Pekka\} and Stephane Heymans and Loreena Hill and Mitja Lainscak and Lam, \{Carolyn S.P.\} and Lund, \{Lars H.\} and Lyon, \{Alexander R.\} and Alexandre Mebazaa and Christian Mueller and Paulus, \{Walter J.\} and Burkert Pieske and Piepoli, \{Massimo F.\} and Frank Ruschitzka and Rutten, \{Frans H.\} and Seferovic, \{Petar M.\} and Solomon, \{Scott D.\} and Shah, \{Sanjiv J.\} and Filippos Triposkiadis and Rolf Wachter and Carsten Tsch{\"o}pe and \{de Boer\}, \{Rudolf A.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors. European Journal of Heart Failure {\textcopyright} 2017 European Society of Cardiology",

year = "2018",

month = jan,

doi = "10.1002/ejhf.1029",

language = "English",

volume = "20",

pages = "16--37",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Oxford University Press",

number = "1",

}

Gorter, TM, van Veldhuisen, DJ, Bauersachs, J, Borlaug, BA, Celutkiene, J, Coats, AJS, Crespo-Leiro, MG, Guazzi, M, Harjola, VP, Heymans, S, Hill, L, Lainscak, M, Lam, CSP, Lund, LH, Lyon, AR, Mebazaa, A, Mueller, C, Paulus, WJ, Pieske, B, Piepoli, MF, Ruschitzka, F, Rutten, FH, Seferovic, PM, Solomon, SD, Shah, SJ, Triposkiadis, F, Wachter, R, Tschöpe, C & de Boer, RA 2018, 'Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology', European Journal of Heart Failure, vol. 20, no. 1, pp. 16-37. https://doi.org/10.1002/ejhf.1029

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. / Gorter, Thomas M.; van Veldhuisen, Dirk J.; Bauersachs, Johann et al.
In: European Journal of Heart Failure, Vol. 20, No. 1, 01.2018, p. 16-37.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Right heart dysfunction and failure in heart failure with preserved ejection fraction

T2 - mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

AU - Gorter, Thomas M.

AU - van Veldhuisen, Dirk J.

AU - Bauersachs, Johann

AU - Borlaug, Barry A.

AU - Celutkiene, Jelena

AU - Coats, Andrew J.S.

AU - Crespo-Leiro, Marisa G.

AU - Guazzi, Marco

AU - Harjola, Veli Pekka

AU - Heymans, Stephane

AU - Hill, Loreena

AU - Lainscak, Mitja

AU - Lam, Carolyn S.P.

AU - Lund, Lars H.

AU - Lyon, Alexander R.

AU - Mebazaa, Alexandre

AU - Mueller, Christian

AU - Paulus, Walter J.

AU - Pieske, Burkert

AU - Piepoli, Massimo F.

AU - Ruschitzka, Frank

AU - Rutten, Frans H.

AU - Seferovic, Petar M.

AU - Solomon, Scott D.

AU - Shah, Sanjiv J.

AU - Triposkiadis, Filippos

AU - Wachter, Rolf

AU - Tschöpe, Carsten

AU - de Boer, Rudolf A.

PY - 2018/1

Y1 - 2018/1

N2 - There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

AB - There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

UR - https://www.scopus.com/pages/publications/85041471654

U2 - 10.1002/ejhf.1029

DO - 10.1002/ejhf.1029

M3 - Article

C2 - 29044932

AN - SCOPUS:85041471654

SN - 1388-9842

VL - 20

SP - 16

EP - 37

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 1

ER -

Gorter TM, van Veldhuisen DJ, Bauersachs J, Borlaug BA, Celutkiene J, Coats AJS et al. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure. 2018 Jan;20(1):16-37. doi: 10.1002/ejhf.1029

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Abstract

Bibliographical note

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