Rising Prevalence of HIV-1 Non-B Subtypes in Belgium: 1983-2001

Joke Snoeck, Kristel Van Laethem, Philippe Hermans, Eric Van Wijngaerden, Inge Derdelinckx, Yoeri Schrooten, David A.M.C. Van De Vijver, Stéphanie De Wit, Nathan Clumeck, Anne Mieke Vandamme*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)


This study documented the HIV-1 subtype distribution in 2 Belgian hospitals and determined predictive demographics for non-B subtypes. Overall, subtype B was the most prevalent subtype in this population, followed by subtypes A and C. Several recombinants were detected, circulating recombinants as well as new ones. We found a rise in non-B subtypes from 0% in 1983 to 57% in 2001. The Cochran-Armitage trend test (P < 0.001) as well as the correlation analysis (R = 0.71, P = 0.0006) was highly significant. Recombinants were also increasing in this patient population from 0% in 1983 to 10% in 2001, with good support from the statistical analyses (trend test P < 0.001; correlation analysis R - 0.67, P = 0.0016). Heterosexual route of infection, black African race, African origin of the virus, and year of diagnosis were predictors for infection with non-B subtypes in multivariate analysis. This analysis indicates that the prevalence of non-B Subtypes and recombinants in this patient population is high and increasing. Gathering demographic and sequence information from newly diagnosed patients could be useful to further follow the spread of non-B subtypes in Belgium and Europe, but subtyping based on sequence information still remains the most reliable method.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number3
Publication statusPublished - 1 Mar 2004
Externally publishedYes


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