Risk evaluation of duodenoscope-associated infections in the Netherlands calls for a heightened awareness of device-related infections: A systematic review

Judith A. Kwakman*, Nicole S. Erler, Margreet C. Vos, Marco J. Bruno

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
21 Downloads (Pure)

Abstract

Background The risk of exogenous infections from endoscopic procedures is often cited as almost negligible (1 infection in 1.8 million procedures); however, this risk is based on older literature and does not seem to match the number of infectious outbreaks due to contaminated duodenoscopes reported after endoscopic retrograde cholangiopancreatography (ERCP). Using Dutch data, we aimed to estimate the minimum risk of duodenoscope-associated infection (DAI) and colonization (DAC) in patients undergoing ERCP. Methods A systematic literature search identified all DAI outbreaks in the Netherlands reported between 2008 and 2019. Included cases were confirmed by molecular matching of patient and duodenoscope cultures. Risk ratios were calculated based on the total number of ERCPs performed during the study period. Results Three outbreaks were reported and published between 2008 and 2018, including 21 confirmed DAI cases and 52 confirmed DAC cases. The estimated number of ERCPs performed during the same period was 181 209-227 006. The calculated minimum estimated DAI risk was approximately 0.01 % and the minimum estimated DAC risk was 0.023 %-0.029 %. Conclusions The estimated risk of DAI in Dutch ERCP practice was at least 180 times higher than previously published risk estimates. The actual risk is likely to be (much) higher due to underreporting of infections caused by multidrug-resistant organisms and sensitive bacteria. Greater awareness by healthcare personnel involved in endoscopy and endoscope cleaning is required, as well as innovative technical solutions to contain and ultimately eliminate DAIs.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalEndoscopy
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2022

Bibliographical note

Funding Information:
J.A. Kwakman has received grant funding from Pentax Medical and Boston Scientific. M.C. Vos has received grant funding from 3M, Pen-tax Medical, and Boston Scientific (development of disposable duode-noscopes). M.J. Bruno is a consultant for Boston Scientific (development of disposable duodenoscopes) and Cook Medical, and has received grant funding from Boston Scientific (development of disposable duodenoscopes), Cook Medical, Pentax Medical, 3M, Mylan, and InterScope. N.S. Erler has no conflicts of interest.

Publisher Copyright:
© 2022 Georg Thieme Verlag. All rights reserved.

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