Risk factors for age-related macular degeneration: Pooled findings from three continents

Wayne Smith, Jacqueline Assink, Ronald Klein, Paul Mitchell*, Caroline C.W. Klaver, Barbara E.K. Klein, Albert Hofman, Susan Jensen, Jie Jin Wang, Paulus T.V.M. De Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

886 Citations (Scopus)


Objective: To assess the prevalence and potential risk factors for late age-related macular degeneration (AMD) in three racially similar populations from North America, Europe, and Australia. Design: Combined analysis of population-based eye disease prevalence data. Participants: There were 14,752 participants with gradable photographs from the Beaver Dam Eye Study (n = 4756), Rotterdam Study (n = 6411), and Blue Mountains Eye Study (n = 3585). Main Outcome Measures: AMD diagnosis was made from masked grading of stereo macular photographs. Final classification of AMD cases was agreed by consensus between study investigators. Results: AMD prevalence was strongly age related. Overall, AMD was present in 0.2% of the combined population aged 55 to 64 years, rising to 13% of the population older than 85 years. Prevalence of neovascular AMD (NV) increased from 0.17% among subjects aged 55 to 64 years to 5.8% for those older than 85 years. Prevalence of pure geographic atrophy (GA) increased from 0.04% to 4.2% for these age groups. There were no significant gender differences in the prevalence of NV or GA. Subjects in the Rotterdam population had a significantly lower age-adjusted and smoking-adjusted risk of NV than subjects in the Beaver Dam and Blue Mountains populations. Apart from age, tobacco smoking was the only risk factor consistently associated with any form of AMD in all sites separately and in pooled analyses over the three sites. Conclusions: These combined data from racially similar communities across three continents provide strong and consistent evidence that tobacco smoking is the principal known preventable exposure associated with any form of AMD.

Original languageEnglish
Pages (from-to)697-704
Number of pages8
Issue number4
Publication statusPublished - Apr 2001


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