Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort

FE van Leeuwen, H Klip, TM Mooij, AMGV de Swaluw, CB Lambalk, M Kortman, Joop Laven, CAM Jansen, FM Helmerhorst, BJ Cohlen, WNP Willemsen, JMJ Smeenk, AHM Simons, Freddy Veen, JLH Evers, PA van Dop, Macklon, Curt Burger

Research output: Contribution to journalArticleAcademicpeer-review

159 Citations (Scopus)
14 Downloads (Pure)


BACKGROUND: Long-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown. METHODS: We identified a nationwide historic cohort of 19 146 women who received IVF treatment in the Netherlands between 1983 and 1995, and a comparison group of 6006 subfertile women not treated with IVF. In 1997-1999, data on reproductive risk factors were obtained from 65% of women and data on subfertility (treatment) were obtained from the medical records. The incidence of ovarian malignancies (including borderline ovarian tumours) through 2007 was assessed through linkage with disease regi RESULTS: After a median follow-up of 14.7 years, the risk of borderline ovarian tumours was increased in the IVF group compared with the general population [standardized incidence ratio (SIR) = 1.76; 95% confidence interval (CI) = 1.16-2.56]. The overall SIR for invasive ovarian cancer was not significantly elevated, but increased with longer follow-up after first IVF (P = 0.02); the SIR was 3.54 (95% CI = 1.62-6.72) after 15 years. The risks of borderline ovarian tumours and of all ovarian mali CONCLUSIONS: Ovarian stimulation for IVF may increase the risk of ovarian malignancies, especially borderline ovarian tumours. More large cohort studies are needed to confirm these findings and to examine the effect of IVF treatment characteristics.
Original languageUndefined/Unknown
Pages (from-to)3456-3465
Number of pages10
JournalHuman Reproduction
Issue number12
Publication statusPublished - 2011

Research programs

  • EMC MM-01-52-07
  • EMC MM-03-52-02-A

Cite this