Rituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia

M R Korte; M J van Heerde; R A de Man; M H G Betjes

Rituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia

M R Korte, M J van Heerde, R A de Man, M H G Betjes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liver transplantation (LTx). We describe an LTx patient with cryoglobulinaemia-associated glomerulonephritis, who was treated successfully with the B cell depleting monoclonal antibody rituximab.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Netherlands Journal of Medicine
Volume	66
Issue number	1
Publication status	Published - Jan 2008

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EMC MM-04-20-02-A
EMC MM-04-39-05

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title = "Rituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia",

abstract = "Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liver transplantation (LTx). We describe an LTx patient with cryoglobulinaemia-associated glomerulonephritis, who was treated successfully with the B cell depleting monoclonal antibody rituximab.",

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AU - de Man, R A

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AB - Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liver transplantation (LTx). We describe an LTx patient with cryoglobulinaemia-associated glomerulonephritis, who was treated successfully with the B cell depleting monoclonal antibody rituximab.

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SP - 27

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JF - Netherlands Journal of Medicine

IS - 1

ER -

Rituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia

Abstract

Bibliographical note

Research programs

UN SDGs

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