Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen; Karl T Butterworth; Anthony J Chalmers; Rob P Coppes; Dirk de Ruysscher; Sophie Dobiasch; John D Fenwick; Patrick V Granton; Stefan H J Heijmans; Mark A Hill; Constantinos Koumenis; Kirsten Lauber; Brian Marples; Katia Parodi; Lucas C G G Persoon; Nick Staut; Anna Subiel; Rianne D W Vaes; Stefan J van Hoof; Ioannis L Verginadis; Jan J Wilkens; Kaye J Williams; George D Wilson; Ludwig J Dubois

doi:10.1088/1361-6560/acaf45

Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis L VerginadisJan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois

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Abstract

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

Original language	English
Article number	06RM01
Journal	Physics in Medicine and Biology
Volume	68
Issue number	6
Early online date	30 Dec 2022
DOIs	https://doi.org/10.1088/1361-6560/acaf45
Publication status	Published - 21 Mar 2023
Externally published	Yes

Bibliographical note

Funding Information:
Katia Parodi acknowledges funding from the European Research Council ERC GA 725539 and would like to thank the entire SIRMIO project team at LMU as well as the broad network of collaborators. Frank Verhaegen acknowledges funding of EUROSTARS ESTAR19115 grant, IRRADION, with contributions from Radalytica SRO (Czech Republic), and the many collaborators over the years.

Funding Information:
Research in the Lauber lab is supported by the Deutsche Forschungsgemeinschaft DFG (SFB1321, Project-ID 329628492, P16), the Bundesministerium fuer Bildung und Forschung BMBF (ZiSStrans NUK047C, and METABOLiST NUK061C), and the Elitenetzwerk Bayern (International graduate program iTarget). Research in the Dubois lab is supported by the European Union’s Horizon 2020 research innovation program under the Marie Skłodowska–Curie Agreement (MSCA) Innovative Training Network (ITN) THERADNET (Project-ID 860245).

Funding Information:
MAH is supported by the CRUK RadNet Oxford centre (Cancer Research UK C6078/A28736)

Funding Information:
KJW is supported by Cancer Research UK via the Cancer Research Manchester Centre (C147/A25254) and RadNet Manchester (C19941/A28701). KTB is supported by the Medical Research Council (MR/V009605/1).

Publisher Copyright:
© 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.

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Roadmap for Precision preclinical x-ray radiation studiesAccepted author manuscript, 3.61 MBLicence: CC BY

Cite this

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H. J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C. G. G., Staut, N., Subiel, A., Vaes, R. D. W., van Hoof, S. J., ... Dubois, L. J. (2023). Roadmap for Precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68(6), Article 06RM01. https://doi.org/10.1088/1361-6560/acaf45

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abstract = "This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.",

author = "Frank Verhaegen and Butterworth, {Karl T} and Chalmers, {Anthony J} and Coppes, {Rob P} and {de Ruysscher}, Dirk and Sophie Dobiasch and Fenwick, {John D} and Granton, {Patrick V} and Heijmans, {Stefan H J} and Hill, {Mark A} and Constantinos Koumenis and Kirsten Lauber and Brian Marples and Katia Parodi and Persoon, {Lucas C G G} and Nick Staut and Anna Subiel and Vaes, {Rianne D W} and {van Hoof}, {Stefan J} and Verginadis, {Ioannis L} and Wilkens, {Jan J} and Williams, {Kaye J} and Wilson, {George D} and Dubois, {Ludwig J}",

note = "Funding Information: Katia Parodi acknowledges funding from the European Research Council ERC GA 725539 and would like to thank the entire SIRMIO project team at LMU as well as the broad network of collaborators. Frank Verhaegen acknowledges funding of EUROSTARS ESTAR19115 grant, IRRADION, with contributions from Radalytica SRO (Czech Republic), and the many collaborators over the years. Funding Information: Research in the Lauber lab is supported by the Deutsche Forschungsgemeinschaft DFG (SFB1321, Project-ID 329628492, P16), the Bundesministerium fuer Bildung und Forschung BMBF (ZiSStrans NUK047C, and METABOLiST NUK061C), and the Elitenetzwerk Bayern (International graduate program iTarget). Research in the Dubois lab is supported by the European Union{\textquoteright}s Horizon 2020 research innovation program under the Marie Sk{\l}odowska–Curie Agreement (MSCA) Innovative Training Network (ITN) THERADNET (Project-ID 860245). Funding Information: MAH is supported by the CRUK RadNet Oxford centre (Cancer Research UK C6078/A28736) Funding Information: KJW is supported by Cancer Research UK via the Cancer Research Manchester Centre (C147/A25254) and RadNet Manchester (C19941/A28701). KTB is supported by the Medical Research Council (MR/V009605/1). Publisher Copyright: {\textcopyright} 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.",

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Verhaegen, F, Butterworth, KT, Chalmers, AJ, Coppes, RP, de Ruysscher, D, Dobiasch, S, Fenwick, JD, Granton, PV, Heijmans, SHJ, Hill, MA, Koumenis, C, Lauber, K, Marples, B, Parodi, K, Persoon, LCGG, Staut, N, Subiel, A, Vaes, RDW, van Hoof, SJ, Verginadis, IL, Wilkens, JJ, Williams, KJ, Wilson, GD & Dubois, LJ 2023, 'Roadmap for Precision preclinical x-ray radiation studies', Physics in Medicine and Biology, vol. 68, no. 6, 06RM01. https://doi.org/10.1088/1361-6560/acaf45

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AU - Verhaegen, Frank

AU - Butterworth, Karl T

AU - Chalmers, Anthony J

AU - Coppes, Rob P

AU - de Ruysscher, Dirk

AU - Dobiasch, Sophie

AU - Fenwick, John D

AU - Granton, Patrick V

AU - Heijmans, Stefan H J

AU - Hill, Mark A

AU - Koumenis, Constantinos

AU - Lauber, Kirsten

AU - Marples, Brian

AU - Parodi, Katia

AU - Persoon, Lucas C G G

AU - Staut, Nick

AU - Subiel, Anna

AU - Vaes, Rianne D W

AU - van Hoof, Stefan J

AU - Verginadis, Ioannis L

AU - Wilkens, Jan J

AU - Williams, Kaye J

AU - Wilson, George D

AU - Dubois, Ludwig J

N1 - Funding Information: Katia Parodi acknowledges funding from the European Research Council ERC GA 725539 and would like to thank the entire SIRMIO project team at LMU as well as the broad network of collaborators. Frank Verhaegen acknowledges funding of EUROSTARS ESTAR19115 grant, IRRADION, with contributions from Radalytica SRO (Czech Republic), and the many collaborators over the years. Funding Information: Research in the Lauber lab is supported by the Deutsche Forschungsgemeinschaft DFG (SFB1321, Project-ID 329628492, P16), the Bundesministerium fuer Bildung und Forschung BMBF (ZiSStrans NUK047C, and METABOLiST NUK061C), and the Elitenetzwerk Bayern (International graduate program iTarget). Research in the Dubois lab is supported by the European Union’s Horizon 2020 research innovation program under the Marie Skłodowska–Curie Agreement (MSCA) Innovative Training Network (ITN) THERADNET (Project-ID 860245). Funding Information: MAH is supported by the CRUK RadNet Oxford centre (Cancer Research UK C6078/A28736) Funding Information: KJW is supported by Cancer Research UK via the Cancer Research Manchester Centre (C147/A25254) and RadNet Manchester (C19941/A28701). KTB is supported by the Medical Research Council (MR/V009605/1). Publisher Copyright: © 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.

PY - 2023/3/21

Y1 - 2023/3/21

N2 - This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

AB - This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

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DO - 10.1088/1361-6560/acaf45

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JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

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Roadmap for Precision preclinical x-ray radiation studies

Abstract

Bibliographical note

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