Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis L VerginadisJan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois

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Abstract

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.

Original languageEnglish
Article number06RM01
JournalPhysics in Medicine and Biology
Volume68
Issue number6
Early online date30 Dec 2022
DOIs
Publication statusPublished - 21 Mar 2023
Externally publishedYes

Bibliographical note

Funding Information:
Katia Parodi acknowledges funding from the European Research Council ERC GA 725539 and would like to thank the entire SIRMIO project team at LMU as well as the broad network of collaborators. Frank Verhaegen acknowledges funding of EUROSTARS ESTAR19115 grant, IRRADION, with contributions from Radalytica SRO (Czech Republic), and the many collaborators over the years.

Funding Information:
Research in the Lauber lab is supported by the Deutsche Forschungsgemeinschaft DFG (SFB1321, Project-ID 329628492, P16), the Bundesministerium fuer Bildung und Forschung BMBF (ZiSStrans NUK047C, and METABOLiST NUK061C), and the Elitenetzwerk Bayern (International graduate program iTarget). Research in the Dubois lab is supported by the European Union’s Horizon 2020 research innovation program under the Marie Skłodowska–Curie Agreement (MSCA) Innovative Training Network (ITN) THERADNET (Project-ID 860245).

Funding Information:
MAH is supported by the CRUK RadNet Oxford centre (Cancer Research UK C6078/A28736)

Funding Information:
KJW is supported by Cancer Research UK via the Cancer Research Manchester Centre (C147/A25254) and RadNet Manchester (C19941/A28701). KTB is supported by the Medical Research Council (MR/V009605/1).

Publisher Copyright:
© 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.

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