This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.
|Journal||Physics in Medicine and Biology|
|Early online date||30 Dec 2022|
|Publication status||Published - 21 Mar 2023|
Bibliographical noteFunding Information:
Katia Parodi acknowledges funding from the European Research Council ERC GA 725539 and would like to thank the entire SIRMIO project team at LMU as well as the broad network of collaborators. Frank Verhaegen acknowledges funding of EUROSTARS ESTAR19115 grant, IRRADION, with contributions from Radalytica SRO (Czech Republic), and the many collaborators over the years.
Research in the Lauber lab is supported by the Deutsche Forschungsgemeinschaft DFG (SFB1321, Project-ID 329628492, P16), the Bundesministerium fuer Bildung und Forschung BMBF (ZiSStrans NUK047C, and METABOLiST NUK061C), and the Elitenetzwerk Bayern (International graduate program iTarget). Research in the Dubois lab is supported by the European Union’s Horizon 2020 research innovation program under the Marie Skłodowska–Curie Agreement (MSCA) Innovative Training Network (ITN) THERADNET (Project-ID 860245).
MAH is supported by the CRUK RadNet Oxford centre (Cancer Research UK C6078/A28736)
KJW is supported by Cancer Research UK via the Cancer Research Manchester Centre (C147/A25254) and RadNet Manchester (C19941/A28701). KTB is supported by the Medical Research Council (MR/V009605/1).
© 2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd.