Robot- and laser-assisted bio-sample preparation: development of an integrated, intuitive system

Cédric Duverney*, Hamed Abbasi, Lina M. Beltrán Bernal, Tino Stauber, Jess G. Snedeker, Philippe C. Cattin, Azhar Zam, Georg Rauter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


The preparation of small-sized biological samples is traditionally performed manually utilizing mechanical tools such as scalpels. The main drawbacks of such methods are a lack of accuracy and repeatability of the resulting cuts and damage to the surrounding tissue due to the high interaction forces and the accompanying mechanical stresses. One way to circumvent these issues is to substitute the mechanical tools for laser light. When used in conjunction with a high-accuracy positioning system, such a preparation procedure enables repeatable cutting of arbitrary geometries while largely preserving the integrity of the surrounding tissue. In this paper, a system leveraging the potential of laser-based ablation for bio-sample preparation is proposed. It integrates and synchronizes all key components with extensive safety features and an intuitive user interface, allowing novice operators to perform sample preparations easily. As a first application, the proposed system has been utilized to create microdamages in mouse tail tendon fascicles. Promising results could be obtained, but careful tuning of the laser parameters and further optimization of the mechanical setup is still required to attain the high repeatability striven for.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalMechanisms and Machine Science
Publication statusE-pub ahead of print - 10 Nov 2020
Externally publishedYes

Bibliographical note

Funding Information:
The authors gratefully acknowledge funding by the Werner Siemens Foundation through the MIRACLE project. They would further like to thank Sascha Martin and team, Department of Physics, University of Basel, Switzerland, for their invaluable support during the mechanical design and manufacturing phases.

Publisher Copyright:
© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.


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