Role of chemokines in the development of secondary and tertiary lymphoid tissues

Tom Cupedo; Reina E. Mebius

doi:10.1016/j.smim.2003.08.002

Role of chemokines in the development of secondary and tertiary lymphoid tissues

Tom Cupedo, Reina E. Mebius^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45⁺CD4⁺CD3^- cells. Hereto CD45 ⁺CD4⁺CD3^- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.

Original language	English
Pages (from-to)	243-248
Number of pages	6
Journal	Seminars in Immunology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2003.08.002
Publication status	Published - Oct 2003
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Georg Kraal for critical reading of the manuscript. T.C. was financially supported by The Netherlands Organization for Scientific Research.

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10.1016/j.smim.2003.08.002

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title = "Role of chemokines in the development of secondary and tertiary lymphoid tissues",

abstract = "Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45 +CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.",

author = "Tom Cupedo and Mebius, {Reina E.}",

note = "Funding Information: We would like to thank Georg Kraal for critical reading of the manuscript. T.C. was financially supported by The Netherlands Organization for Scientific Research. ",

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AU - Cupedo, Tom

AU - Mebius, Reina E.

N1 - Funding Information: We would like to thank Georg Kraal for critical reading of the manuscript. T.C. was financially supported by The Netherlands Organization for Scientific Research.

PY - 2003/10

Y1 - 2003/10

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AB - Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45 +CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.

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JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 5

ER -

Role of chemokines in the development of secondary and tertiary lymphoid tissues

Abstract

Bibliographical note

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