Abstract
This PhD thesis explores the relationship between potassium, tubule remodeling, and kidney function. It begins by reviewing current knowledge on tubule remodeling and salt transport using tissue clearing techniques and examines how dietary potassium restriction affects tubule remodeling in mice.
The thesis also characterizes a mouse model with a kidney-specific deletion of the Cul3 gene, involved in potassium handling, to assess its role in kidney injury. Additionally, it reviews data from a randomized clinical trial (NCT03253172) that tests potassium supplementation to slow down chronic kidney disease (CKD) progression.
Further, the thesis evaluates adherence to potassium-rich diets among CKD patients and their association with blood pressure, kidney function, and comorbidities. A scoring system was developed to assess adherence to CKD-specific dietary recommendations based on nutrient intake, examining correlations with individual characteristics, lifestyle factors, and biomarker levels.
The thesis also characterizes a mouse model with a kidney-specific deletion of the Cul3 gene, involved in potassium handling, to assess its role in kidney injury. Additionally, it reviews data from a randomized clinical trial (NCT03253172) that tests potassium supplementation to slow down chronic kidney disease (CKD) progression.
Further, the thesis evaluates adherence to potassium-rich diets among CKD patients and their association with blood pressure, kidney function, and comorbidities. A scoring system was developed to assess adherence to CKD-specific dietary recommendations based on nutrient intake, examining correlations with individual characteristics, lifestyle factors, and biomarker levels.
| Original language | English |
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| Award date | 18 Dec 2024 |
| Place of Publication | Rotterdam |
| Print ISBNs | 978-94-6510-059-3 |
| Publication status | Published - 18 Dec 2024 |