Role of mesenchymal stromal cell-derived extracellular vesicles in tumour microenvironment

A Adamo, G Dal Collo, R Bazzoni, M Krampera*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

32 Citations (Scopus)
8 Downloads (Pure)

Abstract

Stromal cells, deriving from mesenchymal stromal cells (MSCs), are crucial component of tumour microenvironment and represent key regulators of tumour processes. MSCs can be recruited to the tumour environment and interact with many cellular elements, thus influencing tumour biology. Cell-to-cell communication is in part mediated by the release of extracellular vesicle (EVs). EVs can induce significant molecular changes in recipient cells, delivering bioactive molecules. In this review, we describe the MSC-derived EVs content and discuss their role in different processes related to cancer biology. Furthermore, we summarize chemical or biological EVs modifications aiming to develop more efficient antitumor therapies.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1871
Issue number1
DOIs
Publication statusPublished - Jan 2019
Externally publishedYes

Bibliographical note

Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

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