Abstract
Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4(+) and CD8(+) T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.
Original language | Undefined/Unknown |
---|---|
Pages (from-to) | 461-467 |
Number of pages | 7 |
Journal | Current Opinion in Virology |
Volume | 3 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2013 |
Research programs
- EMC MM-04-20-01
- EMC MM-04-20-02-A