Role of T cell immunity in hepatitis C virus infections

Mark Claassen, HLA Janssen, Andre Boonstra

Research output: Contribution to journalArticleAcademic

28 Citations (Scopus)

Abstract

Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4(+) and CD8(+) T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.
Original languageUndefined/Unknown
Pages (from-to)461-467
Number of pages7
JournalCurrent Opinion in Virology
Volume3
Issue number4
DOIs
Publication statusPublished - 2013

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