Rolle der Echokardiographie in der Diagnostik bei Patienten mit Herzinsuffizienzsymptomen und erhaltener linksventrikulärer Ejektionsfraktion

A. Hagendorff; S. Stöbe; J. Kandels; R. de Boer; C. Tschöpe

doi:10.1007/s00059-022-05118-6

Rolle der Echokardiographie in der Diagnostik bei Patienten mit Herzinsuffizienzsymptomen und erhaltener linksventrikulärer Ejektionsfraktion

Translated title of the contribution: Diagnostic role of echocardiography for patients with heart failure symptoms and preserved left ventricular ejection fraction

A. Hagendorff^*, S. Stöbe, J. Kandels, R. de Boer, C. Tschöpe

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

The syndrome heart failure with preserved ejection fraction (HFpEF) represents patients with different comorbidities and specific etiologies, but with a key and common alteration: an elevation in left ventricular (LV) filling pressure or pulmonary capillary wedge pressure (PCWP). Expert consensuses, society guidelines, and diagnostic scores have been stated to diagnose HFpEF syndrome based mainly on the determination of elevated LV filling pressure or PCWP by transthoracic echocardiography (TTE). Echocardiographic parameters such as early (E) and late diastolic mitral inflow velocity (mitral E/A ratio), septal and lateral mitral annular early diastolic velocity (E′), ratio of the early diastolic mitral inflow and annular velocity (E/E′-ratio), maximal left atrial volume index (LAVI_max), and tricuspid regurgitation peak velocity (V_TR) constitute the pivotal parameters for determining elevated LV filling pressure or PCWP in patients with suspected HFpEF symptoms. Notwithstanding this, taking into consideration the heterogeneity of patients with HFpEF symptoms, the term “HFpEF” should be considered as a syndrome rather than an entity since HFpEF results from different pathological entities that should and can be characterized by echocardiography and multimodality imaging. Comprehensive TTE might help diagnose specific diseases and etiologies by characterization of specific cardiac phenotypes.

Translated title of the contribution	Diagnostic role of echocardiography for patients with heart failure symptoms and preserved left ventricular ejection fraction
Original language	German
Pages (from-to)	293-300
Number of pages	8
Journal	Herz
Volume	47
Issue number	4
DOIs	https://doi.org/10.1007/s00059-022-05118-6
Publication status	Published - Aug 2022
Externally published	Yes

Bibliographical note

Funding Information:
Research of Carsten Tschöpe was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—SFB 1470, project: B02. Research of Rudolf A. de Boer was funded by the Netherlands Heart Foundation (CVON grants 2017-21; 2017-11; 2018-30; 2020B005) and the European Research Council (ERC CoG 818715). For all other authors this research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

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10.1007/s00059-022-05118-6

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title = "Rolle der Echokardiographie in der Diagnostik bei Patienten mit Herzinsuffizienzsymptomen und erhaltener linksventrikul{\"a}rer Ejektionsfraktion",

abstract = "The syndrome heart failure with preserved ejection fraction (HFpEF) represents patients with different comorbidities and specific etiologies, but with a key and common alteration: an elevation in left ventricular (LV) filling pressure or pulmonary capillary wedge pressure (PCWP). Expert consensuses, society guidelines, and diagnostic scores have been stated to diagnose HFpEF syndrome based mainly on the determination of elevated LV filling pressure or PCWP by transthoracic echocardiography (TTE). Echocardiographic parameters such as early (E) and late diastolic mitral inflow velocity (mitral E/A ratio), septal and lateral mitral annular early diastolic velocity (E′), ratio of the early diastolic mitral inflow and annular velocity (E/E′-ratio), maximal left atrial volume index (LAVImax), and tricuspid regurgitation peak velocity (VTR) constitute the pivotal parameters for determining elevated LV filling pressure or PCWP in patients with suspected HFpEF symptoms. Notwithstanding this, taking into consideration the heterogeneity of patients with HFpEF symptoms, the term “HFpEF” should be considered as a syndrome rather than an entity since HFpEF results from different pathological entities that should and can be characterized by echocardiography and multimodality imaging. Comprehensive TTE might help diagnose specific diseases and etiologies by characterization of specific cardiac phenotypes.",

author = "A. Hagendorff and S. St{\"o}be and J. Kandels and {de Boer}, R. and C. Tsch{\"o}pe",

note = "Funding Information: Research of Carsten Tsch{\"o}pe was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—SFB 1470, project: B02. Research of Rudolf A. de Boer was funded by the Netherlands Heart Foundation (CVON grants 2017-21; 2017-11; 2018-30; 2020B005) and the European Research Council (ERC CoG 818715). For all other authors this research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.",

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AU - Kandels, J.

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AU - Tschöpe, C.

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N2 - The syndrome heart failure with preserved ejection fraction (HFpEF) represents patients with different comorbidities and specific etiologies, but with a key and common alteration: an elevation in left ventricular (LV) filling pressure or pulmonary capillary wedge pressure (PCWP). Expert consensuses, society guidelines, and diagnostic scores have been stated to diagnose HFpEF syndrome based mainly on the determination of elevated LV filling pressure or PCWP by transthoracic echocardiography (TTE). Echocardiographic parameters such as early (E) and late diastolic mitral inflow velocity (mitral E/A ratio), septal and lateral mitral annular early diastolic velocity (E′), ratio of the early diastolic mitral inflow and annular velocity (E/E′-ratio), maximal left atrial volume index (LAVImax), and tricuspid regurgitation peak velocity (VTR) constitute the pivotal parameters for determining elevated LV filling pressure or PCWP in patients with suspected HFpEF symptoms. Notwithstanding this, taking into consideration the heterogeneity of patients with HFpEF symptoms, the term “HFpEF” should be considered as a syndrome rather than an entity since HFpEF results from different pathological entities that should and can be characterized by echocardiography and multimodality imaging. Comprehensive TTE might help diagnose specific diseases and etiologies by characterization of specific cardiac phenotypes.

AB - The syndrome heart failure with preserved ejection fraction (HFpEF) represents patients with different comorbidities and specific etiologies, but with a key and common alteration: an elevation in left ventricular (LV) filling pressure or pulmonary capillary wedge pressure (PCWP). Expert consensuses, society guidelines, and diagnostic scores have been stated to diagnose HFpEF syndrome based mainly on the determination of elevated LV filling pressure or PCWP by transthoracic echocardiography (TTE). Echocardiographic parameters such as early (E) and late diastolic mitral inflow velocity (mitral E/A ratio), septal and lateral mitral annular early diastolic velocity (E′), ratio of the early diastolic mitral inflow and annular velocity (E/E′-ratio), maximal left atrial volume index (LAVImax), and tricuspid regurgitation peak velocity (VTR) constitute the pivotal parameters for determining elevated LV filling pressure or PCWP in patients with suspected HFpEF symptoms. Notwithstanding this, taking into consideration the heterogeneity of patients with HFpEF symptoms, the term “HFpEF” should be considered as a syndrome rather than an entity since HFpEF results from different pathological entities that should and can be characterized by echocardiography and multimodality imaging. Comprehensive TTE might help diagnose specific diseases and etiologies by characterization of specific cardiac phenotypes.

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Rolle der Echokardiographie in der Diagnostik bei Patienten mit Herzinsuffizienzsymptomen und erhaltener linksventrikulärer Ejektionsfraktion

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