Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis: a meta-analysis

Ruben B Waalboer; Yannick M Meyer; Boris Galjart; Pim B Olthof; Jeroen L A van Vugt; Dirk J Grünhagen; Cornelis Verhoef

doi:10.1016/j.hpb.2021.08.947

Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis: a meta-analysis

Ruben B Waalboer, Yannick M Meyer, Boris Galjart, Pim B Olthof, Jeroen L A van Vugt, Dirk J Grünhagen, Cornelis Verhoef^*

^*Corresponding author for this work

Surgery

Erasmus MC Cancer Institute

Research output: Contribution to journal › Review article › Academic › peer-review

15 Citations (Scopus)

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Abstract

BACKGROUND: Sarcopenia is defined as either low pre-operative muscle mass or low muscle density on abdominal CT imaging. It has been associated with worse short-term outcomes after surgery for colorectal liver metastases. This study aimed to evaluate whether sarcopenia also impacts long-term survival outcomes in these patients.

METHODS: A random-effects meta-analysis was conducted following the PRISMA guidelines. Overall survival (OS) and disease-free survival (DFS) outcomes were evaluated.

RESULTS: Eleven studies were included, ten reporting on the impact of low muscle mass and four on low muscle density. Sample sizes ranged between 47 and 539 (2124 patients in total). Altogether, 897 (42%) patients were considered sarcopenic, although definitions varied between studies. Median follow-up was 21-74 months. Low muscle mass (hazard ration (HR) 1.35, 95%CI 1.08-1.68) and low muscle density (HR 1.97, 95%CI 1.07-3.62) were associated with impaired OS. Low muscle mass (pooled HR 1.17, 95%CI 0.94-1.46) and low muscle density (pooled HR 1.13, 95%CI 0.85-1.50) were not associated with impaired RFS.

DISCUSSION: Sarcopenia is associated with poorer OS, but not RFS, in patients with CRLM. Additional studies with standardized sarcopenia definitions are needed to better assess the impact of sarcopenia in patients with CRLM.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	HPB
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.hpb.2021.08.947
Publication status	Published - Jan 2022

Bibliographical note

Funding Information:
The authors would like to thank Sabrina Meertens-Gunput for her consultation on the literature search.

Publisher Copyright:
© 2021 The Author(s)

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1-s2.0-S1365182X21015914-mainFinal published version, 997 KBLicence: CC BY

Cite this

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title = "Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis: a meta-analysis",

abstract = "BACKGROUND: Sarcopenia is defined as either low pre-operative muscle mass or low muscle density on abdominal CT imaging. It has been associated with worse short-term outcomes after surgery for colorectal liver metastases. This study aimed to evaluate whether sarcopenia also impacts long-term survival outcomes in these patients.METHODS: A random-effects meta-analysis was conducted following the PRISMA guidelines. Overall survival (OS) and disease-free survival (DFS) outcomes were evaluated.RESULTS: Eleven studies were included, ten reporting on the impact of low muscle mass and four on low muscle density. Sample sizes ranged between 47 and 539 (2124 patients in total). Altogether, 897 (42\%) patients were considered sarcopenic, although definitions varied between studies. Median follow-up was 21-74 months. Low muscle mass (hazard ration (HR) 1.35, 95\%CI 1.08-1.68) and low muscle density (HR 1.97, 95\%CI 1.07-3.62) were associated with impaired OS. Low muscle mass (pooled HR 1.17, 95\%CI 0.94-1.46) and low muscle density (pooled HR 1.13, 95\%CI 0.85-1.50) were not associated with impaired RFS.DISCUSSION: Sarcopenia is associated with poorer OS, but not RFS, in patients with CRLM. Additional studies with standardized sarcopenia definitions are needed to better assess the impact of sarcopenia in patients with CRLM.",

author = "Waalboer, \{Ruben B\} and Meyer, \{Yannick M\} and Boris Galjart and Olthof, \{Pim B\} and \{van Vugt\}, \{Jeroen L A\} and Gr{\"u}nhagen, \{Dirk J\} and Cornelis Verhoef",

note = "Funding Information: The authors would like to thank Sabrina Meertens-Gunput for her consultation on the literature search. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

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doi = "10.1016/j.hpb.2021.08.947",

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T1 - Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis

T2 - a meta-analysis

AU - Waalboer, Ruben B

AU - Meyer, Yannick M

AU - Galjart, Boris

AU - Olthof, Pim B

AU - van Vugt, Jeroen L A

AU - Grünhagen, Dirk J

AU - Verhoef, Cornelis

PY - 2022/1

Y1 - 2022/1

N2 - BACKGROUND: Sarcopenia is defined as either low pre-operative muscle mass or low muscle density on abdominal CT imaging. It has been associated with worse short-term outcomes after surgery for colorectal liver metastases. This study aimed to evaluate whether sarcopenia also impacts long-term survival outcomes in these patients.METHODS: A random-effects meta-analysis was conducted following the PRISMA guidelines. Overall survival (OS) and disease-free survival (DFS) outcomes were evaluated.RESULTS: Eleven studies were included, ten reporting on the impact of low muscle mass and four on low muscle density. Sample sizes ranged between 47 and 539 (2124 patients in total). Altogether, 897 (42%) patients were considered sarcopenic, although definitions varied between studies. Median follow-up was 21-74 months. Low muscle mass (hazard ration (HR) 1.35, 95%CI 1.08-1.68) and low muscle density (HR 1.97, 95%CI 1.07-3.62) were associated with impaired OS. Low muscle mass (pooled HR 1.17, 95%CI 0.94-1.46) and low muscle density (pooled HR 1.13, 95%CI 0.85-1.50) were not associated with impaired RFS.DISCUSSION: Sarcopenia is associated with poorer OS, but not RFS, in patients with CRLM. Additional studies with standardized sarcopenia definitions are needed to better assess the impact of sarcopenia in patients with CRLM.

AB - BACKGROUND: Sarcopenia is defined as either low pre-operative muscle mass or low muscle density on abdominal CT imaging. It has been associated with worse short-term outcomes after surgery for colorectal liver metastases. This study aimed to evaluate whether sarcopenia also impacts long-term survival outcomes in these patients.METHODS: A random-effects meta-analysis was conducted following the PRISMA guidelines. Overall survival (OS) and disease-free survival (DFS) outcomes were evaluated.RESULTS: Eleven studies were included, ten reporting on the impact of low muscle mass and four on low muscle density. Sample sizes ranged between 47 and 539 (2124 patients in total). Altogether, 897 (42%) patients were considered sarcopenic, although definitions varied between studies. Median follow-up was 21-74 months. Low muscle mass (hazard ration (HR) 1.35, 95%CI 1.08-1.68) and low muscle density (HR 1.97, 95%CI 1.07-3.62) were associated with impaired OS. Low muscle mass (pooled HR 1.17, 95%CI 0.94-1.46) and low muscle density (pooled HR 1.13, 95%CI 0.85-1.50) were not associated with impaired RFS.DISCUSSION: Sarcopenia is associated with poorer OS, but not RFS, in patients with CRLM. Additional studies with standardized sarcopenia definitions are needed to better assess the impact of sarcopenia in patients with CRLM.

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DO - 10.1016/j.hpb.2021.08.947

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SN - 1365-182X

VL - 24

SP - 9

EP - 16

JO - HPB

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ER -

Sarcopenia and long-term survival outcomes after local therapy for colorectal liver metastasis: a meta-analysis

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