Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities

B. Valentin; D. Maes-Festen; J. Schoufour; A. Oppewal

doi:10.1111/jir.13078

Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities

B. Valentin^*
, D. Maes-Festen
, J. Schoufour
, A. Oppewal

^*Corresponding author for this work

General Practice

Amsterdam University of Applied Sciences

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

65 Downloads (Pure)

Abstract

Background:

People with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID.

Methods:

In the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (≥50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome).

Results:

The unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48–3.42], P < 0.001), and 2.40 (95% CI 1.40–4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95% CI 1.08–2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95% CI 1.07–3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02–2.59, P = 0.043) and 1.81 (95% CI 1.04–3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively.

Conclusion:

Sarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.

Original language	English
Pages (from-to)	1161-1173
Number of pages	13
Journal	Journal of Intellectual Disability Research
Volume	67
Issue number	11
Early online date	22 Aug 2023
DOIs	https://doi.org/10.1111/jir.13078
Publication status	Published - Nov 2023

Bibliographical note

Funding Information:
This study was carried out with the financial support of the participating care organisations and the Netherlands Organization for Health Research and Development (ZonMw, No. 57,000,003 and No. 314,030,302). The sponsors had no further role in the study.

Funding Information:
The authors thank the management and professionals of the care organisations, Abrona (Huis ter Heide), Amarant (Tilburg) and Ipse deBruggen (Zoetermeer), involved in the HA-ID consortium for financing the data collection of this study and for their collaboration and support. We also thank the participants, their family and caregivers for their collaboration. Finally, we thank Martijn Stuiver for his advice.

Publisher Copyright:
© 2023 The Authors. Journal of Intellectual Disability Research published by MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1111/jir.13078Licence: CC BY-NC

Sarcopenia predicts 5-year mortality in older adults with intellectual disabilitiesFinal published version, 355 KBLicence: CC BY-NC

Cite this

@article{e34cc6bec6d74c66afc4a6c652a3ed26,

title = "Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities",

abstract = "Background: People with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID. Methods: In the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (≥50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome). Results: The unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95\% confidence interval (CI) 1.48–3.42], P < 0.001), and 2.40 (95\% CI 1.40–4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95\% CI 1.08–2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95\% CI 1.07–3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95\% CI 1.02–2.59, P = 0.043) and 1.81 (95\% CI 1.04–3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively. Conclusion: Sarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.",

author = "B. Valentin and D. Maes-Festen and J. Schoufour and A. Oppewal",

note = "Funding Information: This study was carried out with the financial support of the participating care organisations and the Netherlands Organization for Health Research and Development (ZonMw, No. 57,000,003 and No. 314,030,302). The sponsors had no further role in the study. Funding Information: The authors thank the management and professionals of the care organisations, Abrona (Huis ter Heide), Amarant (Tilburg) and Ipse deBruggen (Zoetermeer), involved in the HA-ID consortium for financing the data collection of this study and for their collaboration and support. We also thank the participants, their family and caregivers for their collaboration. Finally, we thank Martijn Stuiver for his advice. Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of Intellectual Disability Research published by MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley \& Sons Ltd.",

year = "2023",

month = nov,

doi = "10.1111/jir.13078",

language = "English",

volume = "67",

pages = "1161--1173",

journal = "Journal of Intellectual Disability Research",

issn = "0964-2633",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "11",

}

TY - JOUR

T1 - Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities

AU - Valentin, B.

AU - Maes-Festen, D.

AU - Schoufour, J.

AU - Oppewal, A.

N1 - Funding Information: This study was carried out with the financial support of the participating care organisations and the Netherlands Organization for Health Research and Development (ZonMw, No. 57,000,003 and No. 314,030,302). The sponsors had no further role in the study. Funding Information: The authors thank the management and professionals of the care organisations, Abrona (Huis ter Heide), Amarant (Tilburg) and Ipse deBruggen (Zoetermeer), involved in the HA-ID consortium for financing the data collection of this study and for their collaboration and support. We also thank the participants, their family and caregivers for their collaboration. Finally, we thank Martijn Stuiver for his advice. Publisher Copyright: © 2023 The Authors. Journal of Intellectual Disability Research published by MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

PY - 2023/11

Y1 - 2023/11

N2 - Background: People with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID. Methods: In the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (≥50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome). Results: The unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48–3.42], P < 0.001), and 2.40 (95% CI 1.40–4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95% CI 1.08–2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95% CI 1.07–3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02–2.59, P = 0.043) and 1.81 (95% CI 1.04–3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively. Conclusion: Sarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.

AB - Background: People with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID. Methods: In the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (≥50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome). Results: The unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48–3.42], P < 0.001), and 2.40 (95% CI 1.40–4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95% CI 1.08–2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95% CI 1.07–3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02–2.59, P = 0.043) and 1.81 (95% CI 1.04–3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively. Conclusion: Sarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.

UR - https://www.scopus.com/pages/publications/85168356022

U2 - 10.1111/jir.13078

DO - 10.1111/jir.13078

M3 - Article

C2 - 37608512

AN - SCOPUS:85168356022

SN - 0964-2633

VL - 67

SP - 1161

EP - 1173

JO - Journal of Intellectual Disability Research

JF - Journal of Intellectual Disability Research

IS - 11

ER -

Sarcopenia predicts 5-year mortality in older adults with intellectual disabilities

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this