TY - JOUR
T1 - SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort
AU - Gigase, Frederieke A.J.
AU - Jessel, Rebecca H.
AU - Kaplowitz, Elianna
AU - Krammer Serology Core Study Group
AU - Boychuk, Natalie
AU - Ohrn, Sophie
AU - Ibroci, Erona
AU - Castro, Juliana
AU - Lynch, Jezelle
AU - Tubassum, Rushna
AU - Balbierz, Amy
AU - Molenaar, Nina M.
AU - Graziani, Mara
AU - Missall, Roy
AU - Flores, Tammy
AU - Stern, Toni
AU - Carreno, Juan Manuel
AU - Krammer, Florian
AU - Adler, Alan
AU - Brody, Rachel I.
AU - Lesseur, Corina
AU - Chen, Jia
AU - Ellington, Sascha
AU - Galang, Romeo R.
AU - Snead, Margaret C.
AU - Howell, Elizabeth
AU - Stone, Joanne
AU - Bergink, Veerle
AU - Dolan, Siobhan
AU - Lieb, Whitney
AU - Rommel, Anna Sophie
AU - de Witte, Lotje D.
AU - Janevic, Teresa
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024/6
Y1 - 2024/6
N2 - Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting and the role of the immune system is currently unclear. This prospective cohort study investigated the interaction of antenatal SARS-CoV-2 infection, changes in cytokine and HS-CRP levels, birthweight and gestational age at birth. 2352 pregnant participants from New York City (2020–2022) were included. Plasma levels of interleukin (IL)-1β, IL-6, IL-17A and high-sensitivity C-reactive protein (HS-CRP) were quantified in blood specimens obtained across pregnancy. Quantile and linear regression models were conducted to 1) assess the impact of antenatal SARS-CoV-2 infection, overall and by timing of detection of SARS-CoV-2 positivity (< 20 weeks versus ≥ 20 weeks), on birthweight and gestational age at delivery; 2) examine the relationship between SARS-CoV-2 infection and maternal immune changes during pregnancy. All models were adjusted for maternal demographic and obstetric factors and pandemic timing. Birthweight models were additionally adjusted for gestational age at delivery and fetal sex. Immune marker models were also adjusted for gestational age at specimen collection and multiplex assay batch. 371 (15.8%) participants were infected with SARS-CoV-2 during pregnancy, of which 98 (26.4%) were infected at < 20 weeks gestation. Neither SARS-CoV-2 infection in general nor in early or late pregnancy was associated with lower birthweight nor earlier gestational age at delivery. Further, we did not observe cytokine or HS-CRP changes in response to SARS-CoV-2 infection and thus found no evidence to support a potential association between immune dysregulation and the diversity in pregnancy outcomes following infection.
AB - Associations between antenatal SARS-CoV-2 infection and pregnancy outcomes have been conflicting and the role of the immune system is currently unclear. This prospective cohort study investigated the interaction of antenatal SARS-CoV-2 infection, changes in cytokine and HS-CRP levels, birthweight and gestational age at birth. 2352 pregnant participants from New York City (2020–2022) were included. Plasma levels of interleukin (IL)-1β, IL-6, IL-17A and high-sensitivity C-reactive protein (HS-CRP) were quantified in blood specimens obtained across pregnancy. Quantile and linear regression models were conducted to 1) assess the impact of antenatal SARS-CoV-2 infection, overall and by timing of detection of SARS-CoV-2 positivity (< 20 weeks versus ≥ 20 weeks), on birthweight and gestational age at delivery; 2) examine the relationship between SARS-CoV-2 infection and maternal immune changes during pregnancy. All models were adjusted for maternal demographic and obstetric factors and pandemic timing. Birthweight models were additionally adjusted for gestational age at delivery and fetal sex. Immune marker models were also adjusted for gestational age at specimen collection and multiplex assay batch. 371 (15.8%) participants were infected with SARS-CoV-2 during pregnancy, of which 98 (26.4%) were infected at < 20 weeks gestation. Neither SARS-CoV-2 infection in general nor in early or late pregnancy was associated with lower birthweight nor earlier gestational age at delivery. Further, we did not observe cytokine or HS-CRP changes in response to SARS-CoV-2 infection and thus found no evidence to support a potential association between immune dysregulation and the diversity in pregnancy outcomes following infection.
UR - http://www.scopus.com/inward/record.url?scp=85188792658&partnerID=8YFLogxK
U2 - 10.1016/j.jri.2024.104243
DO - 10.1016/j.jri.2024.104243
M3 - Article
C2 - 38522364
AN - SCOPUS:85188792658
SN - 0165-0378
VL - 163
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
M1 - 104243
ER -