SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model

Bart L. Haagmans, Danny Noack, Nisreen M.A. Okba, Wentao Li, Chunyan Wang, Theo Bestebroer, Rory de Vries, Sander Herfst, Dennis de Meulder, Elwin Verveer, Peter van Run, Mart M. Lamers, Bart Rijnders, Casper Rokx, Frank van Kuppeveld, Frank Grosveld, Dubravka Drabek, Corine Geurts van Kessel, Marion Koopmans, Berend Jan BoschThijs Kuiken, Barry Rockx

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

Effective clinical intervention strategies for coronavirus disease 2019 (COVID-19) are urgently needed. Although several clinical trials have evaluated use of convalescent plasma containing virus-neutralizing antibodies, levels of neutralizing antibodies are usually not assessed and the effectiveness has not been proven. We show that hamsters treated prophylactically with a 1:2560 titer of human convalescent plasma or a 1:5260 titer of monoclonal antibody were protected against weight loss, had a significant reduction of virus replication in the lungs, and showed reduced pneumonia. Interestingly, this protective effect was lost with a titer of 1:320 of convalescent plasma. These data highlight the importance of screening plasma donors for high levels of neutralizing antibodies. Our data show that prophylactic administration of high levels of neutralizing antibody, either monoclonal or from convalescent plasma, prevent severe SARS-CoV-2 pneumonia in a hamster model, and could be used as an alternative or complementary to other antiviral treatments for COVID-19.

Original languageEnglish
Pages (from-to)2020-2028
Number of pages9
JournalThe Journal of infectious diseases
Volume223
Issue number12
DOIs
Publication statusPublished - 15 Jun 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

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