TY - JOUR
T1 - SARS-CoV-2 Non-structural protein 1(NSP1) mutation virulence and natural selection
T2 - Evolutionary trends in the six continents
AU - Ghaleh, Samira Salami
AU - Rahimian, Karim
AU - Mahmanzar, Mohammadamin
AU - Mahdavi, Bahar
AU - Tokhanbigli, Samaneh
AU - Sisakht, Mahsa Mollapour
AU - Farhadi, Amin
AU - Bakhtiari, Mahsa Mousakhan
AU - Kuehu, Donna Lee
AU - Deng, Youping
N1 - Funding Information:
This work was partially supported by the NIH grants 5P30GM114737 , 5P20GM103466 , 5U54MD007601 , 1P20GM139753 , 5P30CA071789 , 2U54CA14372 .
Publisher Copyright:
© 2022
PY - 2023/1/2
Y1 - 2023/1/2
N2 - Objective: Rapid transmission and reproduction of RNA viruses prepare conducive conditions to have a high rate of mutations in their genetic sequence. The viral mutations make adapt the severe acute respiratory syndrome coronavirus 2 in the host environment and help the evolution of the virus then also caused a high mortality rate by the virus that threatens worldwide health. Mutations and adaptation help the virus to escape confrontations that are done against it. Methods: In the present study, we analyzed 6,510,947 sequences of non-structural protein 1 as one of the conserved regions of the virus to find out frequent mutations and substitute amino acids in comparison with the wild type. NSP1 mutations rate divided into continents were different. Results: Based on this continental categorization, E87D in global vision and also in Europe notably increased. The E87D mutation has signed up to January 2022 as the first frequent mutation observed. The remarkable mutations, H110Y and R24C have the second and third frequencies, respectively. Conclusion: According to the important role of non-structural protein 1 on the host mRNA translation, developing drug design against the protein could be so hopeful to find more effective ways the control and then treatment of the global pandemic coronavirus disease 2019.
AB - Objective: Rapid transmission and reproduction of RNA viruses prepare conducive conditions to have a high rate of mutations in their genetic sequence. The viral mutations make adapt the severe acute respiratory syndrome coronavirus 2 in the host environment and help the evolution of the virus then also caused a high mortality rate by the virus that threatens worldwide health. Mutations and adaptation help the virus to escape confrontations that are done against it. Methods: In the present study, we analyzed 6,510,947 sequences of non-structural protein 1 as one of the conserved regions of the virus to find out frequent mutations and substitute amino acids in comparison with the wild type. NSP1 mutations rate divided into continents were different. Results: Based on this continental categorization, E87D in global vision and also in Europe notably increased. The E87D mutation has signed up to January 2022 as the first frequent mutation observed. The remarkable mutations, H110Y and R24C have the second and third frequencies, respectively. Conclusion: According to the important role of non-structural protein 1 on the host mRNA translation, developing drug design against the protein could be so hopeful to find more effective ways the control and then treatment of the global pandemic coronavirus disease 2019.
UR - http://www.scopus.com/inward/record.url?scp=85144091524&partnerID=8YFLogxK
U2 - 10.1016/j.virusres.2022.199016
DO - 10.1016/j.virusres.2022.199016
M3 - Article
C2 - 36473671
AN - SCOPUS:85144091524
SN - 0168-1702
VL - 323
JO - Virus Research
JF - Virus Research
M1 - 199016
ER -
