Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

RA Barker; Inez Beaufort

doi:10.1016/j.pneurobio.2013.04.003

Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

RA Barker, Inez Beaufort

Public Health

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental therapies? Over the last 20 years there has been a revolution in our ability to make stem cells from different sources and use them for therapeutic gain in disorders of the brain. These cells, which are defined by their capacity to proliferate indefinitely as well as differentiate into selective phenotypic cell types, are viewed as being especially attractive for studying disease processes and for grafting in patients with chronic incurable neurodegenerative disorders of the CNS such as Parkinson's disease

Original language	Undefined/Unknown
Pages (from-to)	63-73
Number of pages	11
Journal	Progress in Neurobiology
Volume	110
DOIs	https://doi.org/10.1016/j.pneurobio.2013.04.003
Publication status	Published - 2013

Research programs

EMC OR-01-74-01

Access to Document

10.1016/j.pneurobio.2013.04.003

http://hdl.handle.net/1765/74185

Cite this

@article{34cc2ae02dad48dd930b5273c5d05111,

title = "Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain",

abstract = "Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental therapies? Over the last 20 years there has been a revolution in our ability to make stem cells from different sources and use them for therapeutic gain in disorders of the brain. These cells, which are defined by their capacity to proliferate indefinitely as well as differentiate into selective phenotypic cell types, are viewed as being especially attractive for studying disease processes and for grafting in patients with chronic incurable neurodegenerative disorders of the CNS such as Parkinson's disease",

author = "RA Barker and Inez Beaufort",

year = "2013",

doi = "10.1016/j.pneurobio.2013.04.003",

language = "Undefined/Unknown",

volume = "110",

pages = "63--73",

journal = "Progress in Neurobiology",

issn = "0301-0082",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

AU - Barker, RA

AU - Beaufort, Inez

PY - 2013

Y1 - 2013

N2 - Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental therapies? Over the last 20 years there has been a revolution in our ability to make stem cells from different sources and use them for therapeutic gain in disorders of the brain. These cells, which are defined by their capacity to proliferate indefinitely as well as differentiate into selective phenotypic cell types, are viewed as being especially attractive for studying disease processes and for grafting in patients with chronic incurable neurodegenerative disorders of the CNS such as Parkinson's disease

AB - Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental therapies? Over the last 20 years there has been a revolution in our ability to make stem cells from different sources and use them for therapeutic gain in disorders of the brain. These cells, which are defined by their capacity to proliferate indefinitely as well as differentiate into selective phenotypic cell types, are viewed as being especially attractive for studying disease processes and for grafting in patients with chronic incurable neurodegenerative disorders of the CNS such as Parkinson's disease

U2 - 10.1016/j.pneurobio.2013.04.003

DO - 10.1016/j.pneurobio.2013.04.003

M3 - Article

C2 - 23665410

SN - 0301-0082

VL - 110

SP - 63

EP - 73

JO - Progress in Neurobiology

JF - Progress in Neurobiology

ER -