Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia

A. B. Schreuder; R. J. Overduin; N. C. Peltenburg; L. de Boer; F. A.J.A. Bodewes; T. G.J. Derks

doi:10.1002/jmd2.12414

Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia

A. B. Schreuder^*, R. J. Overduin, N. C. Peltenburg, L. de Boer, F. A.J.A. Bodewes, T. G.J. Derks

^*Corresponding author for this work

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Abstract

No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	JIMD Reports
Volume	65
Issue number	4
DOIs	https://doi.org/10.1002/jmd2.12414
Publication status	Published - Jul 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM.

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Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type IaFinal published version, 654 KBLicence: CC BY

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title = "Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia",

abstract = "No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.",

author = "Schreuder, {A. B.} and Overduin, {R. J.} and Peltenburg, {N. C.} and {de Boer}, L. and Bodewes, {F. A.J.A.} and Derks, {T. G.J.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM.",

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month = jul,

doi = "10.1002/jmd2.12414",

language = "English",

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AU - Schreuder, A. B.

AU - Overduin, R. J.

AU - Peltenburg, N. C.

AU - de Boer, L.

AU - Bodewes, F. A.J.A.

AU - Derks, T. G.J.

PY - 2024/7

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N2 - No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.

AB - No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.

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U2 - 10.1002/jmd2.12414

DO - 10.1002/jmd2.12414

M3 - Article

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SN - 2192-8304

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JO - JIMD Reports

JF - JIMD Reports

IS - 4

ER -

Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia

Abstract

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