Screening for intracranial hypertension in craniosynostosis

Treatment in craniosynostosis is focused on the treatment and prevention of intracranial hypertension (ICH). There is however, still a search for the ideal screeningmethod to detect ICH.
In this thesis we therefore evaluate additional non-invasive screeningmethods such as optical coherence tomography (OCT) and occipitofrontal head circumference (OFC) to optimize screening in craniosynostosis. Furthermore, a feared consequence of ICH is vision loss. However, the prevalence of retinal abnormalities due to ICH and it's effect of vision are unknown. We therefore used OCT to establish the prevalence of retinal abnormalities and it's consequences on visual acuity.
This thesis underscores the importance of tailored screening programs for
various craniosynostosis types. OCT proves to be a valuable addition to ICH screening and is recommended to be used in conjunction with fundoscopy and OFC measurement. Thinning of the optic nerve head was rarely found and was not associated with visual loss.
Above all, the greatest value lies in discussing the outcomes of various screening
methods and imaging within the craniofacial team to reach a well-balanced and
a collaborative decision on the treatment of a craniosynostosis patient.