Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium

Leslie Grasset; Joshua C. Bis; Stefan Frenzel; Daniel Kojis; Jeannette Simino; Amber Yaqub; Alexa Beiser; Claudine Berr; Jan Bressler; Robin Bülow; Charles S. DeCarli; Alison E. Fohner; Laura B. Harrington; Catherine Helmer; M. Arfan Ikram; Rozenn N. Lemaitre; Oscar L. Lopez; W. T. Longstreth; Julia Neitzel; Michelle C. Odden; Priya Palta; Carsten O. Schmidt; Rajesh Talluri; Meike W. Vernooij; Henry Völzke; Trudy Voortman; Quest Whalen; Katharina Wittfeld; Hans J. Grabe; Thomas H. Mosley; Bruce M. Psaty; Frank J. Wolters; Sudha Seshadri; Carole Dufouil

doi:10.1002/alz.70148

Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium

Leslie Grasset^*
, Joshua C. Bis
, Stefan Frenzel
, Daniel Kojis
, Jeannette Simino
, Amber Yaqub
, Alexa Beiser
, Claudine Berr
, Jan Bressler
, Robin Bülow
, Charles S. DeCarli
, Alison E. Fohner
, Laura B. Harrington
, Catherine Helmer
, M. Arfan Ikram
, Rozenn N. Lemaitre
, Oscar L. Lopez
, W. T. Longstreth
, Julia Neitzel
, Michelle C. Odden

Priya Palta, Carsten O. Schmidt, Rajesh Talluri, Meike W. Vernooij, Henry Völzke, Trudy Voortman, Quest Whalen, Katharina Wittfeld, Hans J. Grabe, Thomas H. Mosley, Bruce M. Psaty, Frank J. Wolters, Sudha Seshadri, Carole Dufouil

^*Corresponding author for this work

University Bordeaux
University of Washington
University Medicine Greifswald
Boston University School of Public Health Boston Massachusetts USA
Memory Impairment and Neurodegenerative Dementia (MIND)
Boston School of Medicine
INM - Institute for Neurosciences of Montpellier
Human Genetics Center School of Public Health University of Texas Health Science Center at Houston Houston Texas USA
Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany
Imaging of Dementia and Aging (IDeA) Laboratory
Cardiovascular Health Research Unit University of Washington Seattle Washington USA
Bernard J. Tyson School of Medicine
University of Washington (Seattle)
University of Pittsburgh
Stanford University School of Medicine
University of North Carolina (Chapel Hill)
Institute for Community Medicine University Medicine of Greifswald Greifswald Germany
John D. Bower School of Population Health
German Center for Neurodegenerative Disease (DZNE) partner site Rostock/Greifswald Greisfswald Germany
University of Mississippi Medical Center
The University of Texas Health Science Center at San Antonio
Pole de santé publique Centre Hospitalier Universitaire (CHU) de Bordeaux

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

63 Downloads (Pure)

Abstract

INTRODUCTION:

To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers.

METHODS:

Data from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed.

RESULTS:

Higher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume.

DISCUSSION:

This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience.

Highlights:

Education level, marital status, and physical activity are thought to contribute to resilience against ADRD.
We used random-effects meta-analysis to summarize results from six community-based samples from the CCC.
In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia.
In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.

Original language	English
Article number	e70148
Pages (from-to)	e70148
Journal	Alzheimer's and Dementia
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/alz.70148
Publication status	Published - Apr 2025

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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10.1002/alz.70148Licence: CC BY

Selected social and lifestyle correlates of brain health markersFinal published version, 458 KBLicence: CC BY

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Grasset, L., Bis, J. C., Frenzel, S., Kojis, D., Simino, J., Yaqub, A., Beiser, A., Berr, C., Bressler, J., Bülow, R., DeCarli, C. S., Fohner, A. E., Harrington, L. B., Helmer, C., Ikram, M. A., Lemaitre, R. N., Lopez, O. L., Longstreth, W. T., Neitzel, J., ... Dufouil, C. (2025). Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium. Alzheimer's and Dementia, 21(4), e70148. Article e70148. https://doi.org/10.1002/alz.70148

@article{c79a1e74f40b4194a9fb9ad01d4c267a,

title = "Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium",

abstract = "INTRODUCTION: To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS: Data from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed. RESULTS: Higher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95\% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95\% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume. DISCUSSION: This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience. Highlights: Education level, marital status, and physical activity are thought to contribute to resilience against ADRD. We used random-effects meta-analysis to summarize results from six community-based samples from the CCC. In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia. In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.",

author = "Leslie Grasset and Bis, \{Joshua C.\} and Stefan Frenzel and Daniel Kojis and Jeannette Simino and Amber Yaqub and Alexa Beiser and Claudine Berr and Jan Bressler and Robin B{\"u}low and DeCarli, \{Charles S.\} and Fohner, \{Alison E.\} and Harrington, \{Laura B.\} and Catherine Helmer and Ikram, \{M. Arfan\} and Lemaitre, \{Rozenn N.\} and Lopez, \{Oscar L.\} and Longstreth, \{W. T.\} and Julia Neitzel and Odden, \{Michelle C.\} and Priya Palta and Schmidt, \{Carsten O.\} and Rajesh Talluri and Vernooij, \{Meike W.\} and Henry V{\"o}lzke and Trudy Voortman and Quest Whalen and Katharina Wittfeld and Grabe, \{Hans J.\} and Mosley, \{Thomas H.\} and Psaty, \{Bruce M.\} and Wolters, \{Frank J.\} and Sudha Seshadri and Carole Dufouil",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Alzheimer's \& Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2025",

month = apr,

doi = "10.1002/alz.70148",

language = "English",

volume = "21",

pages = "e70148",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

Grasset, L, Bis, JC, Frenzel, S, Kojis, D, Simino, J, Yaqub, A, Beiser, A, Berr, C, Bressler, J, Bülow, R, DeCarli, CS, Fohner, AE, Harrington, LB, Helmer, C, Ikram, MA, Lemaitre, RN, Lopez, OL, Longstreth, WT, Neitzel, J, Odden, MC, Palta, P, Schmidt, CO, Talluri, R, Vernooij, MW, Völzke, H, Voortman, T, Whalen, Q, Wittfeld, K, Grabe, HJ, Mosley, TH, Psaty, BM, Wolters, FJ, Seshadri, S & Dufouil, C 2025, 'Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium', Alzheimer's and Dementia, vol. 21, no. 4, e70148, pp. e70148. https://doi.org/10.1002/alz.70148

TY - JOUR

T1 - Selected social and lifestyle correlates of brain health markers

T2 - the Cross‐Cohort Collaboration Consortium

AU - Grasset, Leslie

AU - Bis, Joshua C.

AU - Frenzel, Stefan

AU - Kojis, Daniel

AU - Simino, Jeannette

AU - Yaqub, Amber

AU - Beiser, Alexa

AU - Berr, Claudine

AU - Bressler, Jan

AU - Bülow, Robin

AU - DeCarli, Charles S.

AU - Fohner, Alison E.

AU - Harrington, Laura B.

AU - Helmer, Catherine

AU - Ikram, M. Arfan

AU - Lemaitre, Rozenn N.

AU - Lopez, Oscar L.

AU - Longstreth, W. T.

AU - Neitzel, Julia

AU - Odden, Michelle C.

AU - Palta, Priya

AU - Schmidt, Carsten O.

AU - Talluri, Rajesh

AU - Vernooij, Meike W.

AU - Völzke, Henry

AU - Voortman, Trudy

AU - Whalen, Quest

AU - Wittfeld, Katharina

AU - Grabe, Hans J.

AU - Mosley, Thomas H.

AU - Psaty, Bruce M.

AU - Wolters, Frank J.

AU - Seshadri, Sudha

AU - Dufouil, Carole

PY - 2025/4

Y1 - 2025/4

N2 - INTRODUCTION: To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS: Data from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed. RESULTS: Higher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume. DISCUSSION: This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience. Highlights: Education level, marital status, and physical activity are thought to contribute to resilience against ADRD. We used random-effects meta-analysis to summarize results from six community-based samples from the CCC. In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia. In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.

AB - INTRODUCTION: To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS: Data from six community-based samples from the Cross-Cohort Collaboration Consortium were analyzed. Self-reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross-sectional MRI markers were meta-analyzed. RESULTS: Higher education level was associated with lower dementia risk (hazard ratio [HR] = 0.65, 95% confidence interval [CI] = 0.59; 0.72 vs low level) but not significantly with brain MRI markers. Compared with being unmarried, being married was only associated with higher total brain and hippocampal volumes. Being physically active was associated with lower dementia risk (HR = 0.73, 95% CI = 0.52; 1.04), as well as larger total brain volume and smaller white matter hyperintensity volume. DISCUSSION: This study provides further evidence regarding the contribution of education level and physical activity to dementia resilience. Highlights: Education level, marital status, and physical activity are thought to contribute to resilience against ADRD. We used random-effects meta-analysis to summarize results from six community-based samples from the CCC. In this cross-cohort meta-analysis, higher education level and being physically active were associated with lower risk of dementia. In cross-sectional analyses, being married was associated with larger TBV and HV, while being physically active was associated with larger TBV and lower WMHV.

U2 - 10.1002/alz.70148

DO - 10.1002/alz.70148

M3 - Article

C2 - 40207408

SN - 1552-5260

VL - 21

SP - e70148

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 4

M1 - e70148

ER -

Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium

Abstract

Bibliographical note

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