Serial RV wall stress measurements: association with right ventricular function in repaired Tetralogy of Fallot patients

Savine Minderhoud, Alexander Hirsch, Francesca Marin, Isabella Kardys, Jose Felix Rodriguez Matas, Claudio Chiastra, Jolien Hesselink, Jolanda Wentzel, W.A. Helbing, Ali Akyildiz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Downloads (Pure)

Abstract

Background: Optimal timing of pulmonary valve replacement (PVR) in Tetralogy of Fallot (TOF) patients remains challenging. Ventricular wall stress is considered to be an early marker of right ventricular (RV) dysfunction.

Objectives: To investigate the association of RV wall stresses and their change over time with functional parameters in TOF patients.

Methods: Ten TOF patients after surgical repair with moderate/severe pulmonary regurgitation were included. At two timepoints (median follow-up time 7.2 years), patient-specific computational biventricular models for wall stress assessment were created using CMR short-axis cine images and echocardiography-based RV pressures. RV ejection fraction (RVEF), NT-proBNP and cardiopulmonary exercise tests were used as outcome measures reflecting RV function. Associations between regional RV diastolic wall stress and RV function were investigated using linear mixed models.

Results: Increased wall stress correlated with lower RV mass (rrm = −0.70, p = 0.017) and lower RV mass-to-volume (rrm = −0.80, p = 0.003) using repeated measures. Wall stress decreased significantly over time, especially in patients with a stable RVEF (p < 0.001). Higher wall stress was independently associated with lower RVEF, adjusted for left ventricular ejection fraction, RV end-diastolic volume and time since initial surgery (decrease of 1.27% RVEF per kPa increase in wall stress, p = 0.029) using repeated measurements. No association was found between wall stress, NT-proBNP, and exercise capacity.

Conclusions: Using a computational method to calculate wall stress locally in geometrically complex ventricles, we demonstrated that lower wall stress might be important to maintain ventricular function. RV wall stress assessment can be used in serial follow-up, and is potentially an early marker of impending RV dysfunction.
Original languageEnglish
Article number1256792
Number of pages12
JournalFrontiers in Cardiovascular Medicine
Volume10
DOIs
Publication statusPublished - 19 Oct 2023

Bibliographical note

Publisher Copyright:
2023 Minderhoud, Hirsch, Marin, Kardys, Rodríguez-Matas, Chiastra, Roos-Hesselink, Wentzel, Helbing and Akyildiz.

Fingerprint

Dive into the research topics of 'Serial RV wall stress measurements: association with right ventricular function in repaired Tetralogy of Fallot patients'. Together they form a unique fingerprint.

Cite this