TY - JOUR
T1 - Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary
AU - Haagsman, Annika
AU - Reuter, Gábor
AU - Duizer, Erwin
AU - Nagy, Gyuláné
AU - Herremans, Tineke
AU - Koopmans, Marion
AU - Szücs, György
PY - 2007/7
Y1 - 2007/7
N2 - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.
AB - Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries. The aim of this study was to assess the role HEV as causative agent in acute non-A, non-B, and non-C hepatitis patients in Hungary. 10.5% of the 264 acute non-A, non-B, and non-C hepatitis patients tested had anti-HEV IgG and 1.9% had anti-HEV IgM as tested by ELISA. After confirmation by Western blot 6.1% of the acute non-A, non-B, and non-C hepatitis patients had anti-HEV IgG antibodies only and 1.1% of the patients had both IgG and IgM. All 19 patients that were positive for anti-HEV IgG and/ or IgM tested negative for HEV RN A by PCR. Only a small proportion of the acute hepatitis cases in the southwest of Hungary are assumed to be attributed to HEV infection, however, hepatitis E should be considered along with hepatitis A, B, and C in the diagnosis of acute hepatitis.
UR - http://www.scopus.com/inward/record.url?scp=34249912113&partnerID=8YFLogxK
U2 - 10.1002/jmv.20869
DO - 10.1002/jmv.20869
M3 - Article
C2 - 17516521
AN - SCOPUS:34249912113
SN - 0146-6615
VL - 79
SP - 927
EP - 930
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 7
ER -
