Serum anti-Mullerian hormone and inhibin B concentrations are not useful predictors of ovarian response during ovulation induction treatment with recombinant follicle-stimulating hormone in women with polycystic ovary syndrome

Sharon Lie Fong, I Schipper, Frank Jong, Axel Themmen, JA Visser, Joop Laven

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Objective: To describe changes of anti-Mullerian hormone (AMH) and inhibin B during low-dose gonadotropin ovulation induction (OI) treatment in women with polycystic ovary syndrome (PCOS), and thus disturbed selection of the dominant follicle. Design: Observational study. Setting: A referral fertility clinic. Patient(s): Women with PCOS (n = 48) and normo-ovulatory women (n = 23). Intervention(s) and Main Outcome Measure(s): Serum AMH, inhibin B, FSH, and E(2) concentrations were measured at start of stimulation, on the day of follicle selection, and at administration of hCG during OI cycles and were compared with concentration measured during the normal menstrual cycle. Result(s): Development of a single dominant follicle was observed in 92% of all OI cycles, reflected by similar E2 concentrations compared with those in spontaneous cycles. AMH concentrations were constant during low-dose ovarian stimulation. Inhibin B concentrations remained elevated in patients with PCOS, suggesting prolonged survival of small antral follicles, whereas in controls inhibin B concentrations declined during the late follicular phase. Conclusion(s): The lack of change in AMH and inhibin B concentrations suggest that follicle dynamics during low-dose stimulation seem different from those during controlled ovarian hyperstimulation. In addition, constant AMH and inhibin B levels suggest that neither AMH nor inhibin B is an accurate marker of ovarian response after low-dose gonadotropin OI in patients with PCOS. (Fertil Steril (R) 2011;96:459-63. (C) 2011 by American Society for Reproductive Medicine.)
Original languageUndefined/Unknown
Pages (from-to)459-463
Number of pages5
JournalFertility & Sterility
Issue number2
Publication statusPublished - 2011

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