Serum Anti-Mullerian Hormone Levels in Healthy Females: A Nomogram Ranging from Infancy to Adulthood

Sharon Lie Fong, Jenny Visser, CK Welt, Yolanda de Rijke, Rene Eijkemans, FJ Broekmans, Eva Maria Roes, WHM Peters, Anita Hokken - Koelega, BCJM Fauser, Axel Themmen, Frank Jong, I Schipper, Joop Laven

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Abstract

Context: Anti-Mullerian hormone (AMH) is an accurate marker of ovarian reserve. However, sufficiently large sets of normative data from infancy to the end of reproductive life are scarce. Objective: This study was an assessment of serum AMH levels in healthy females. Subjects: In 804 healthy females ranging from infancy until the end of the reproductive period, serum AMH levels were measured with an enzyme-linked immunometric assay. All adults had regular menstrual cycles. The majority was proven fertile and none of them had used oral contraceptive pills prior to study inclusion. Results: In the total cohort, AMH was inversely correlated with age (r = -0.24; P < 0.001). The age at which the maximum AMH value was attained was at 15.8 yr. In girls younger than 15.8 yr, serum AMH and age were positively correlated (r = +0.18; P = 0.007). Thereafter AMH levels remained stable (r = -0.33; P = 0.66), whereas from the age of 25.0 yr onward, an inverse correlation between AMH and age (r = -0.47; P < 0.001) was observed. At any given age, considerable interindividual differences Conclusion: During infancy AMH levels increase, whereas during adolescence, a plateau until the age of 25 yr was observed. From the age of 25 yr onward, serum AMH levels correlate inversely with age, implying that AMH is applicable as a marker of ovarian reserve only in women of 25 yr old and older. Our nomogram may facilitate counseling women on their reproductive potential. (J Clin Endocrinol Metab 97: 4650-4655, 2012)
Original languageUndefined/Unknown
Pages (from-to)4650-4655
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number12
DOIs
Publication statusPublished - 2012

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