Serum HBsAg Decline During Long-term Potent Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B and Prediction of HBsAg Loss

Roeland Zoutendijk, Bettina Hansen, Hanneke van Vuuren, Charles Boucher, HLA Janssen

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Nucleos(t)ide analogues strongly inhibit viral replication in chronic hepatitis B (CHB) infection, but knowledge of their long-term effect on serum hepatitis B surface antigen (HBsAg) levels and HBsAg loss is lacking. Seventy-five CHB patients with virological response (VR) to ETV or TDF were included. HBsAg decline 2 years after VR was most pronounced in HBeAg-positive patients. Age, alanine aminotransferase, and HBeAg loss were associated with HBsAg decline in HBeAg-positive patients. Predicted median time to HBsAg loss was 36 years for HBeAg-positive and 39 years for HBeAg-negative patients. Thus, most patients treated with ETV and TDF will probably need decades of therapy to achieve HBsAg loss.
Original languageUndefined/Unknown
Pages (from-to)415-418
Number of pages4
JournalJournal of Infectious Diseases
Issue number3
Publication statusPublished - 2011

Research programs

  • EMC MM-04-20-01
  • EMC MM-04-20-02-A
  • EMC MM-04-27-01
  • EMC NIHES-01-66-01

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