Severe thrombotic tendency associated with a type I plasminogen deficiency

Frank W.G. Leebeek*, Eduard A.R. Knot, Jan Wouter Ten Cate, Daan W. Traas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)


We report a 45‐year‐old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, electrophoretic mobility on crossed immunoelectrophoresis, molecular weight, and binding to lysine sepharose. All other hemostatic parameters predisposing to recurrent thrombosis were normal. A stimulation test with desmopressin acetate (DDAVP) showed a normal plasma rise of both tissue plasminogen activator and factor VIIIR:WF. This isolated plasminogen deficiency apparently is due to a decreased synthesis of a normal plasminogen molecule and is associated with a severe thrombotic tendency.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalAmerican Journal of Hematology
Issue number1
Publication statusPublished - Jan 1989
Externally publishedYes


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