TY - JOUR
T1 - Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries
T2 - implications for migraine
AU - de Vries, Tessa
AU - Boucherie, Deirdre M.
AU - Chan, Kayi Y.
AU - Rubio-Beltrán, Eloísa
AU - Labastida-Ramírez, Alejandro
AU - Labruijere, Sieneke
AU - Gupta, Saurabh
AU - van den Bogaerdt, Antoon
AU - Vincent, Arnaud
AU - Dammers, Ruben
AU - Danser, A. H.Jan
AU - MaassenVanDenBrink, Antoinette
N1 - Publisher Copyright:
© International Headache Society 2024.
PY - 2024/7
Y1 - 2024/7
N2 - BACKGROUND: Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries. METHODS: CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.RESULTS: In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups. CONCLUSIONS: Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.
AB - BACKGROUND: Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries. METHODS: CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.RESULTS: In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups. CONCLUSIONS: Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.
UR - http://www.scopus.com/inward/record.url?scp=85199390621&partnerID=8YFLogxK
U2 - 10.1177/03331024241254088
DO - 10.1177/03331024241254088
M3 - Article
C2 - 39043230
AN - SCOPUS:85199390621
SN - 0333-1024
VL - 44
JO - Cephalalgia : an international journal of headache
JF - Cephalalgia : an international journal of headache
IS - 7
M1 - 3331024241254088
ER -