Shape-based glioma mutation prediction using magnetic resonance imaging

SJC Schielen, Jochem Spoor, REM Fleischeuer, HB Verheul, Sieger Leenstra, S Zinger

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review


Gliomas are the most frequently occurring primary brain tumors. Determination of the IDH-mutation (Isocitrate DeHydrogenase) in these tumors improves classification and predicts survival. Currently, the only way of determining the mutation status is through a brain biopsy, which is an invasive procedure. This paper concerns the classification of a brain tumor's mutation status through medical imaging. This study proposes a method based on shape description and machine learning. Magnetic resonance images of brain tumors were manually segmented through contour drawing, then analyzed through mathematical shape description. The extracted features were classified using multiple algorithms of which Random Undersampling Boosted Trees gave the highest accuracy. An accuracy of 86.4% was found using leave-one-out cross-validation on a data set of 13 IDH-positive and 9 IDH-wild-type gliomas. The results indicate the feasibility of the proposed approach, but further research on a larger data set is required.

Original languageEnglish
Title of host publication28th European Signal Processing Conference, EUSIPCO 2020 - Proceedings
Number of pages5
ISBN (Electronic)9789082797053
Publication statusPublished - 24 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 European Signal Processing Conference, EUSIPCO. All rights reserved.

Research programs

  • EMC OR-01


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