Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice

EJ van Beers, CFJ van Tuijn, MR Mac Gillavry, A van Giessen, John-john Schnog, BJ Biemond

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37 Citations (Scopus)


In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In 104 adult sickle cell patients pain rate was related to a history of acute chest syndromes, avascular osteonecrosis, iron overload, priapism and cholelithiasis. However, major disease-related complications, such as microalbuminuria and pulmonary hypertension, were detected in 23% and 24% respectively of patients without painful crises in the study period underlining the importance of systematic screening for developing organ damage in sickle cell patients irrespective of pain rate.
Original languageUndefined/Unknown
Pages (from-to)757-760
Number of pages4
Issue number5
Publication statusPublished - 2008

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