Sickle cell patients are characterized by a reduced glycocalyx volume

EJ van Beers; M Nieuwdrop; AJ Duits; LM Evers; John-john Schnog; BJ Biemond

doi:10.3324/haematol.12027

Sickle cell patients are characterized by a reduced glycocalyx volume

EJ van Beers, M Nieuwdrop, AJ Duits, LM Evers, John-john Schnog, BJ Biemond

Hematology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

Original language	Undefined/Unknown
Pages (from-to)	307-308
Number of pages	2
Journal	Haematologica
Volume	93
Issue number	2
DOIs	https://doi.org/10.3324/haematol.12027
Publication status	Published - 2008

Research programs

EMC MM-02-41-04

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10.3324/haematol.12027

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http://hdl.handle.net/1765/29628

Cite this

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title = "Sickle cell patients are characterized by a reduced glycocalyx volume",

abstract = "The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.",

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AU - van Beers, EJ

AU - Nieuwdrop, M

AU - Duits, AJ

AU - Evers, LM

AU - Schnog, John-john

AU - Biemond, BJ

PY - 2008

Y1 - 2008

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AB - The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

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DO - 10.3324/haematol.12027

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