Sickle cell patients are characterized by a reduced glycocalyx volume

EJ van Beers, M Nieuwdrop, AJ Duits, LM Evers, John-john Schnog, BJ Biemond

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Abstract

The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbS beta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbS beta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1x10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.
Original languageUndefined/Unknown
Pages (from-to)307-308
Number of pages2
JournalHaematologica
Volume93
Issue number2
DOIs
Publication statusPublished - 2008

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