Signaling proteins that regulate NaCL chemotaxis responses modulate longevity in C. elegans

Hannes Lans, Martijn P.J. Dekkers, Renate K. Hukema, Nathan J. Bialas, Michel R. Leroux, Gert Jansen*

*Corresponding author for this work

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

3 Citations (Scopus)

Abstract

The lifespan of the nematode Caenorhabditis elegans is regulated by sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 14 Gα subunits and a Gγ subunit. We have identified seven sensory Gα subunits that modulate lifespan. Genetic experiments suggest that multiple sensory signaling pathways exist that modulate lifespan and that some G proteins function in multiple pathways, most of which, but probably not all, involve insulinIGF-1 like signaling. Interestingly, of the sensory G proteins involved in regulating lifespan, only one Gα probably functions directly in the detection of sensory cues. The other G proteins seem to function in modulating the sensitivity of the sensory neurons. We hypothesize that in addition to the mere detection of sensory cues, regulation of the sensitivity of sensory neurons also plays a role in the regulation of lifespan.

Original languageEnglish
Title of host publicationInternational Symposium on Olfaction and Taste
Pages682-687
Number of pages6
DOIs
Publication statusPublished - Jul 2009

Publication series

SeriesAnnals of the New York Academy of Sciences
Volume1170
ISSN0077-8923

Bibliographical note

©2009 New York Academy of Sciences

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