TY - GEN
T1 - Signaling proteins that regulate NaCL chemotaxis responses modulate longevity in C. elegans
AU - Lans, Hannes
AU - Dekkers, Martijn P.J.
AU - Hukema, Renate K.
AU - Bialas, Nathan J.
AU - Leroux, Michel R.
AU - Jansen, Gert
N1 - ©2009 New York Academy of Sciences
PY - 2009/7
Y1 - 2009/7
N2 - The lifespan of the nematode Caenorhabditis elegans is regulated by sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 14 Gα subunits and a Gγ subunit. We have identified seven sensory Gα subunits that modulate lifespan. Genetic experiments suggest that multiple sensory signaling pathways exist that modulate lifespan and that some G proteins function in multiple pathways, most of which, but probably not all, involve insulinIGF-1 like signaling. Interestingly, of the sensory G proteins involved in regulating lifespan, only one Gα probably functions directly in the detection of sensory cues. The other G proteins seem to function in modulating the sensitivity of the sensory neurons. We hypothesize that in addition to the mere detection of sensory cues, regulation of the sensitivity of sensory neurons also plays a role in the regulation of lifespan.
AB - The lifespan of the nematode Caenorhabditis elegans is regulated by sensory signals detected by the amphid neurons. In these neurons, C. elegans expresses at least 14 Gα subunits and a Gγ subunit. We have identified seven sensory Gα subunits that modulate lifespan. Genetic experiments suggest that multiple sensory signaling pathways exist that modulate lifespan and that some G proteins function in multiple pathways, most of which, but probably not all, involve insulinIGF-1 like signaling. Interestingly, of the sensory G proteins involved in regulating lifespan, only one Gα probably functions directly in the detection of sensory cues. The other G proteins seem to function in modulating the sensitivity of the sensory neurons. We hypothesize that in addition to the mere detection of sensory cues, regulation of the sensitivity of sensory neurons also plays a role in the regulation of lifespan.
UR - http://www.scopus.com/inward/record.url?scp=68649118866&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04362.x
DO - 10.1111/j.1749-6632.2009.04362.x
M3 - Conference proceeding
C2 - 19686212
AN - SCOPUS:68649118866
SN - 9781573317382
T3 - Annals of the New York Academy of Sciences
SP - 682
EP - 687
BT - International Symposium on Olfaction and Taste
ER -