Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Yuki Nakanishi, Angeles Duran, Antoine L'Hermitte, Phillip M. Shelton, Naoko Nakanishi, Miguel Reina-Campos, Jianfeng Huang, Ferran Soldevila, Bas J.G. Baaten, Daniele V.F. Tauriello, Elias A. Castilla, Munveer S. Bhangoo, Fei Bao, Darren Sigal, Maria T. Diaz-Meco, Jorge Moscat*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Serrated adenocarcinomas are an aggressive and treatment-resistant form of colorectal cancer. Nakanishi et al. show that expression of atypical PKCs is reduced in human serrated tumors and that their loss results in spontaneous serrated tumorigenesis with stromal activation and immunosuppression in mice. The simultaneous inhibition of stromal activation combined with anti-PD-L1 showed synergistic therapeutic potential.

Original languageEnglish
Pages (from-to)1132-1147.e7
JournalImmunity
Volume49
Issue number6
DOIs
Publication statusPublished - 18 Dec 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

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