TY - JOUR
T1 - Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
AU - Willer, Cristen J.
AU - Speliotes, Elizabeth K.
AU - GIANT Consortium
AU - Loos, Ruth J.F.
AU - Li, Shengxu
AU - Lindgren, Cecilia M.
AU - Heid, Iris M.
AU - Berndt, Sonja I.
AU - Elliott, Amanda L.
AU - Jackson, Anne U.
AU - Lamina, Claudia
AU - Lettre, Guillaume
AU - Lim, Noha
AU - Lyon, Helen N.
AU - McCarroll, Steven A.
AU - Papadakis, Konstantinos
AU - Qi, Lu
AU - Randall, Joshua C.
AU - Roccasecca, Rosa Maria
AU - Sanna, Serena
AU - Scheet, Paul
AU - Weedon, Michael N.
AU - Wheeler, Eleanor
AU - Zhao, Jing Hua
AU - Jacobs, Leonie C.
AU - Prokopenko, Inga
AU - Soranzo, Nicole
AU - Tanaka, Toshiko
AU - Timpson, Nicholas J.
AU - Almgren, Peter
AU - Bennett, Amanda
AU - Bergman, Richard N.
AU - Bingham, Sheila A.
AU - Bonnycastle, Lori L.
AU - Brown, Morris
AU - Burtt, Noël P.
AU - Chines, Peter
AU - Coin, Lachlan
AU - Collins, Francis S.
AU - Connell, John M.
AU - Cooper, Cyrus
AU - Smith, George Davey
AU - Dennison, Elaine M.
AU - Deodhar, Parimal
AU - Elliott, Paul
AU - Hofman, Albert
AU - Kraft, Peter
AU - Rivadeneira, Fernando
AU - Van Duijn, Cornelia M.
AU - Zillikens, M. Carola
AU - Uitterlinden, André G.
PY - 2009/1
Y1 - 2009/1
N2 - Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 × 10-8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
AB - Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 × 10-8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
UR - http://www.scopus.com/inward/record.url?scp=58149163142&partnerID=8YFLogxK
U2 - 10.1038/ng.287
DO - 10.1038/ng.287
M3 - Article
C2 - 19079261
AN - SCOPUS:58149163142
SN - 1061-4036
VL - 41
SP - 25
EP - 34
JO - Nature Genetics
JF - Nature Genetics
IS - 1
ER -
