Skin autofluorescence, a non-invasive biomarker of advanced glycation end products, and its relation to radiographic and MRI based osteoarthritis

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Objectives: Accumulation of advanced glycation end products (AGEs) in articular cartilage during aging has been proposed as a mechanism involved in the development of osteoarthritis (OA). Therefore, we investigated a cross-sectional relationship between skin AGEs, a biomarker for systemic AGEs accumulation, and OA. Methods: Skin AGEs were estimated with the AGE Reader™ as skin autofluorescence (SAF). Knee and hip X-rays were scored according to Kellgren and Lawrence (KL) system. KL-sum score of all four joints was calculated per participant to assess severity of overall radiographic OA (ROA) including or excluding those with prosthesis. Knee MRI of tibiofemoral joint (TFMRI) was assessed for cartilage loss. Sex-stratified regression models were performed after testing interaction with SAF. Results: 2,153 participants were included for this cross-sectional analysis. In women (n = 1,206) for one unit increase in SAF, the KL-sum score increased by 1.15 (95% confidence interval = 1.00–1.33) but excluding women with prosthesis, there was no KL-sum score increase [0.96 (0.83–1.11)]. SAF was associated with higher prevalence of prosthesis [Odds ratio, OR = 1.67 (1.10–2.54)] but not with ROA [OR = 0.83 (0.61–1.14)] when compared to women with no ROA. In men (n = 947), there was inconclusive association between SAF and KL sum score or prosthesis. For TFMRI (n = 103 women), SAF was associated with higher prevalence of cartilage loss, full-thickness [OR = 5.44 (1.27–23.38)] and partial-thickness [OR = 1.45 (0.38–5.54)], when compared to participants with no cartilage loss. Conclusion: Higher SAF in women was associated with higher prosthesis prevalence and a trend towards higher cartilage loss on MRI. Our data presents inconclusive results between SAF and ROA in both sexes.

Original languageEnglish
Pages (from-to)1631-1639
Number of pages9
JournalOsteoarthritis and Cartilage
Issue number12
Publication statusPublished - Dec 2022

Bibliographical note

Funding Information:
The Rotterdam Study is supported by Erasmus Medical Center and Erasmus University , Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw) , the Research Institute for Diseases in the Elderly (RIDE) , the Netherlands Genomics Initiative , the Ministry of Education, Culture and Science , the Ministry for Health, Welfare and Sports , the European Commission (DG XII) , and the Municipality of Rotterdam . The Jaap Schouten Foundation established in Rotterdam, The Netherlands, provided funding for the analyses of Advanced Glycation End Products related to musculoskeletal health in the Rotterdam Study. The funding sources had no role in the study design, data collection, analysis, and interpretation, writing of the report, or decision to submit the article for publication.

Publisher Copyright:
© 2022 The Author(s)


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