Skin autofluorescence is elevated in neovascular age-related macular degeneration

D J Mulder; M Bieze; R Graaff; A J Smit; J M M Hooymans

doi:10.1136/bjo.2009.162990

Skin autofluorescence is elevated in neovascular age-related macular degeneration

D J Mulder^*
, M Bieze
, R Graaff
, A J Smit
, J M M Hooymans

^*Corresponding author for this work

University Medical Centre Groningen

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND/AIMS:

Skin autofluorescence (AF) is a non-invasive marker for advanced glycation endproducts (AGE) in tissues, making use of their characteristic AF pattern. The aim of this study was to investigate whether skin AF is increased in patients with neovascular age-related macular degeneration (AMD) compared with healthy controls.

METHODS:

Skin AF was assessed in 73 consecutive patients with active and documented neovascular AMD without evidence for diabetic or hypertensive retinopathy and in 31 healthy age-matched controls. Exclusion criteria were: known renal disease, current inflammatory or malignant disease, or skin type V or VI. Skin AF was measured on the forearm and was calculated as a ratio of mean intensities detected from the skin between 420-600 and 300-420 nm. Student t test and chi(2) test were used to compare differences between groups.

RESULTS:

Skin AF was increased in neovascular AMD compared with controls (2.57+/-0.68 vs 2.23+/-0.63 arbitrary units x 10(-2); p=0.018). In patients without vascular risk factors or cardiovascular disease, skin AF was not significantly higher than that of the controls. Skin AF correlated with age in both patients and controls.

CONCLUSION:

Skin AF is increased in patients with neovascular AMD, suggesting that AMD is accompanied by enhanced systemic AGE accumulation, which may indicate a role in the pathophysiology of AMD.

Original language	English
Pages (from-to)	622-625
Journal	British Journal of Ophthalmology
Volume	94
Issue number	5
DOIs	https://doi.org/10.1136/bjo.2009.162990
Publication status	E-pub ahead of print - 22 Mar 2016
Externally published	Yes

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10.1136/bjo.2009.162990

Skin autofluorescence is elevated in neovascular age-related macular degenerationFinal published version, 108 KBLicence: Article 25fa Dutch Copyright Act

Cite this

@article{9c92bafbe93747e5969a8aff0b961c2b,

title = "Skin autofluorescence is elevated in neovascular age-related macular degeneration",

abstract = "BACKGROUND/AIMS:Skin autofluorescence (AF) is a non-invasive marker for advanced glycation endproducts (AGE) in tissues, making use of their characteristic AF pattern. The aim of this study was to investigate whether skin AF is increased in patients with neovascular age-related macular degeneration (AMD) compared with healthy controls. METHODS:Skin AF was assessed in 73 consecutive patients with active and documented neovascular AMD without evidence for diabetic or hypertensive retinopathy and in 31 healthy age-matched controls. Exclusion criteria were: known renal disease, current inflammatory or malignant disease, or skin type V or VI. Skin AF was measured on the forearm and was calculated as a ratio of mean intensities detected from the skin between 420-600 and 300-420 nm. Student t test and chi(2) test were used to compare differences between groups. RESULTS:Skin AF was increased in neovascular AMD compared with controls (2.57+/-0.68 vs 2.23+/-0.63 arbitrary units x 10(-2); p=0.018). In patients without vascular risk factors or cardiovascular disease, skin AF was not significantly higher than that of the controls. Skin AF correlated with age in both patients and controls. CONCLUSION:Skin AF is increased in patients with neovascular AMD, suggesting that AMD is accompanied by enhanced systemic AGE accumulation, which may indicate a role in the pathophysiology of AMD.",

author = "Mulder, \{D J\} and M Bieze and R Graaff and Smit, \{A J\} and Hooymans, \{J M M\}",

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doi = "10.1136/bjo.2009.162990",

language = "English",

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T1 - Skin autofluorescence is elevated in neovascular age-related macular degeneration

AU - Mulder, D J

AU - Bieze, M

AU - Graaff, R

AU - Smit, A J

AU - Hooymans, J M M

PY - 2016/3/22

Y1 - 2016/3/22

N2 - BACKGROUND/AIMS:Skin autofluorescence (AF) is a non-invasive marker for advanced glycation endproducts (AGE) in tissues, making use of their characteristic AF pattern. The aim of this study was to investigate whether skin AF is increased in patients with neovascular age-related macular degeneration (AMD) compared with healthy controls. METHODS:Skin AF was assessed in 73 consecutive patients with active and documented neovascular AMD without evidence for diabetic or hypertensive retinopathy and in 31 healthy age-matched controls. Exclusion criteria were: known renal disease, current inflammatory or malignant disease, or skin type V or VI. Skin AF was measured on the forearm and was calculated as a ratio of mean intensities detected from the skin between 420-600 and 300-420 nm. Student t test and chi(2) test were used to compare differences between groups. RESULTS:Skin AF was increased in neovascular AMD compared with controls (2.57+/-0.68 vs 2.23+/-0.63 arbitrary units x 10(-2); p=0.018). In patients without vascular risk factors or cardiovascular disease, skin AF was not significantly higher than that of the controls. Skin AF correlated with age in both patients and controls. CONCLUSION:Skin AF is increased in patients with neovascular AMD, suggesting that AMD is accompanied by enhanced systemic AGE accumulation, which may indicate a role in the pathophysiology of AMD.

AB - BACKGROUND/AIMS:Skin autofluorescence (AF) is a non-invasive marker for advanced glycation endproducts (AGE) in tissues, making use of their characteristic AF pattern. The aim of this study was to investigate whether skin AF is increased in patients with neovascular age-related macular degeneration (AMD) compared with healthy controls. METHODS:Skin AF was assessed in 73 consecutive patients with active and documented neovascular AMD without evidence for diabetic or hypertensive retinopathy and in 31 healthy age-matched controls. Exclusion criteria were: known renal disease, current inflammatory or malignant disease, or skin type V or VI. Skin AF was measured on the forearm and was calculated as a ratio of mean intensities detected from the skin between 420-600 and 300-420 nm. Student t test and chi(2) test were used to compare differences between groups. RESULTS:Skin AF was increased in neovascular AMD compared with controls (2.57+/-0.68 vs 2.23+/-0.63 arbitrary units x 10(-2); p=0.018). In patients without vascular risk factors or cardiovascular disease, skin AF was not significantly higher than that of the controls. Skin AF correlated with age in both patients and controls. CONCLUSION:Skin AF is increased in patients with neovascular AMD, suggesting that AMD is accompanied by enhanced systemic AGE accumulation, which may indicate a role in the pathophysiology of AMD.

U2 - 10.1136/bjo.2009.162990

DO - 10.1136/bjo.2009.162990

M3 - Article

C2 - 19726430

SN - 0007-1161

VL - 94

SP - 622

EP - 625

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 5

ER -

Skin autofluorescence is elevated in neovascular age-related macular degeneration

Abstract

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