SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections

D Micha, DC Guo, Y Hilhorst-Hofstee, Fop Kooten, D Atmaja, E Overwater, FK Cayami, ES Regalado, R van Uffelen, H Venselaar, SMH Faradz, G Vriend, MM Weiss, EA Sistermans, A Maugeri, DM Milewicz, G Pals, FS van Dijk

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We report three families with arterial aneurysms and dissections in which variants predicted to be pathogenic were identified in SMAD2. Moreover, one variant occurred de novo in a proband with unaffected parents. SMAD2 is a strong candidate gene for arterial aneurysms and dissections given its role in the TGF-beta signaling pathway. Furthermore, although SMAD2 and SMAD3 probably have functionally distinct roles in cell signaling, they are structurally very similar. Our findings indicate that SMAD2 mutations are associated with arterial aneurysms and dissections and are in accordance with the observation that patients with pathogenic variants in genes encoding proteins involved in the TGF-beta signaling pathway exhibit arterial aneurysms and dissections as key features (C) 2015 Wiley Periodicals, Inc.
Original languageUndefined/Unknown
Pages (from-to)1145-1149
Number of pages5
JournalHuman Mutation
Issue number12
Publication statusPublished - 2015

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