Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases

Lindsey Oudijk, Michael den Bakker, Hop, M Cohen, AK Charles, R Alaggio, CM Coffin, Ronald de Krijger

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45 Citations (Scopus)


Aims: To report a large series of solitary and multiple myofibromas with systematic clinicopathological correlations. Methods and results: We report on 114 patients with myofibromas, 97 of which were solitary and 17 multifocal. The age at presentation ranged from newborn to 70 years. All multifocal myofibromas and 91% of solitary myofibromas occurred in children. The head and neck region was the most common site (n = 43), followed by the trunk (n = 24), lower limbs (n = 14), upper limbs (n = 11), and viscera (n = 4). Solitary and multifocal myofibromas stained positively for smooth muscle actin (SMA) in 95% and Conclusions: Solitary and multiple myofibromas are benign tumours that predominantly occur in infancy and childhood. Myofibromas occur especially in the head and neck region, and are characterized by SMA and, to a lesser extent, MSA expression. The clinical course is self-limiting, and local excision appears to be sufficient.
Original languageUndefined/Unknown
Pages (from-to)E1-E11
Issue number6B
Publication statusPublished - 2012

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