Solute transport in continuous arteriovenous hemodiafiltration: A new mathematical model applied to clinical data

H. H. Vincent; F. J. Van Ittersum; E. Akcahuseyin; M. C. Vos; W. A. Van Duyl; M. A.D.H. Schalekamp

doi:10.1159/000169957

Solute transport in continuous arteriovenous hemodiafiltration: A new mathematical model applied to clinical data

H. H. Vincent, F. J. Van Ittersum, E. Akcahuseyin, M. C. Vos, W. A. Van Duyl, M. A.D.H. Schalekamp

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

A mathematical model of continuous arteriovenous hemodiafiltration is presented, by which the diffusive mass transfer coefficient(K(d)) for a solute may be calculated from blood, filtrate and dialysate flow rates and solute concentrations. The model was applied to clinical data obtained with 0.6-m² AN69 capillary dialyzers that had been used for up to 5 days. The diffusive mass transfer coefficient proved to depend on dialysate flow rate. Furthermore, it was related to the membrane index of ultrafiltration, as measured in the clinic, and to the filter resistance to blood flow. Measurement of these filter characteristics allowed a reasonable prediction of solute clearance.

Original language	English
Pages (from-to)	149-159
Number of pages	11
Journal	Blood Purification
Volume	8
Issue number	3
DOIs	https://doi.org/10.1159/000169957
Publication status	Published - 1990

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abstract = "A mathematical model of continuous arteriovenous hemodiafiltration is presented, by which the diffusive mass transfer coefficient(K(d)) for a solute may be calculated from blood, filtrate and dialysate flow rates and solute concentrations. The model was applied to clinical data obtained with 0.6-m2 AN69 capillary dialyzers that had been used for up to 5 days. The diffusive mass transfer coefficient proved to depend on dialysate flow rate. Furthermore, it was related to the membrane index of ultrafiltration, as measured in the clinic, and to the filter resistance to blood flow. Measurement of these filter characteristics allowed a reasonable prediction of solute clearance.",

author = "Vincent, {H. H.} and {Van Ittersum}, {F. J.} and E. Akcahuseyin and Vos, {M. C.} and {Van Duyl}, {W. A.} and Schalekamp, {M. A.D.H.}",

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AU - Vos, M. C.

AU - Van Duyl, W. A.

AU - Schalekamp, M. A.D.H.

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Solute transport in continuous arteriovenous hemodiafiltration: A new mathematical model applied to clinical data

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