TY - JOUR
T1 - Sources of hepatitis E virus genotype 3 in the Netherlands
AU - Rutjes, Saskia A.
AU - Lodder, Willemijn J.
AU - Lodder-Verschoor, Froukje
AU - Van Den Berg, Harold H.J.L.
AU - Vennema, Harry
AU - Duizer, Erwin
AU - Koopmans, Marion
AU - De Husman, Ana Maria Roda
PY - 2009/3
Y1 - 2009/3
N2 - Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.
AB - Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.
UR - http://www.scopus.com/inward/record.url?scp=63849275956&partnerID=8YFLogxK
U2 - 10.3201/eid1503.071472
DO - 10.3201/eid1503.071472
M3 - Article
C2 - 19239749
AN - SCOPUS:63849275956
VL - 15
SP - 381
EP - 387
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 3
ER -
