Sources of hepatitis E virus genotype 3 in the Netherlands

Saskia A. Rutjes; Willemijn J. Lodder; Froukje Lodder-Verschoor; Harold H.J.L. Van Den Berg; Harry Vennema; Erwin Duizer; Marion Koopmans; Ana Maria Roda De Husman

doi:10.3201/eid1503.071472

Sources of hepatitis E virus genotype 3 in the Netherlands

Saskia A. Rutjes
, Willemijn J. Lodder
, Froukje Lodder-Verschoor
, Harold H.J.L. Van Den Berg
, Harry Vennema
, Erwin Duizer
, Marion Koopmans
, Ana Maria Roda De Husman

Virology

National Institute of Public Health and the Environment

Research output: Contribution to journal › Article › Academic › peer-review

140 Citations (Scopus)

47 Downloads (Pure)

Abstract

Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.

Original language	English
Pages (from-to)	381-387
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	15
Issue number	3
DOIs	https://doi.org/10.3201/eid1503.071472
Publication status	Published - Mar 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3201/eid1503.071472Licence: Unspecified

Sources of Hepatitis E VirusFinal published version, 207 KBLicence: Unspecified

Cite this

@article{320be2a0f624446c82e505e9ab5b2f5d,

title = "Sources of hepatitis E virus genotype 3 in the Netherlands",

abstract = "Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53\% of pig farms, 4\% of wild boar feces, and 17\% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35\% and 43\% of the animal and environmental sequences and 75\% and 6\%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.",

author = "Rutjes, \{Saskia A.\} and Lodder, \{Willemijn J.\} and Froukje Lodder-Verschoor and \{Van Den Berg\}, \{Harold H.J.L.\} and Harry Vennema and Erwin Duizer and Marion Koopmans and \{De Husman\}, \{Ana Maria Roda\}",

year = "2009",

month = mar,

doi = "10.3201/eid1503.071472",

language = "English",

volume = "15",

pages = "381--387",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "3",

}

TY - JOUR

T1 - Sources of hepatitis E virus genotype 3 in the Netherlands

AU - Rutjes, Saskia A.

AU - Lodder, Willemijn J.

AU - Lodder-Verschoor, Froukje

AU - Van Den Berg, Harold H.J.L.

AU - Vennema, Harry

AU - Duizer, Erwin

AU - Koopmans, Marion

AU - De Husman, Ana Maria Roda

PY - 2009/3

Y1 - 2009/3

N2 - Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.

AB - Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans.

UR - https://www.scopus.com/pages/publications/63849275956

U2 - 10.3201/eid1503.071472

DO - 10.3201/eid1503.071472

M3 - Article

C2 - 19239749

AN - SCOPUS:63849275956

SN - 1080-6040

VL - 15

SP - 381

EP - 387

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -

Sources of hepatitis E virus genotype 3 in the Netherlands

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this